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ISSN 2448-8909 (Print)

2009, Number 3

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Med Crit 2009; 23 (3)

Use of activated factor VII in critically ill patients: Experience with 54 cases

Rodríguez RJ, Montes OSMA, Villalobos SJA, Domínguez JS, Granillo JF

Language: Spanish
References: 13
Page: 148-153
PDF size: 71.75 Kb.


ABSTRACT

Introduction: Severe bleeding in the critically ill patient is an entity that often increases time of hospitalization and mortality. Use of recombinant activated factor VII (rFVIIa) has shown to be effective to treat hemorrhage with a low rate of adverse effects. Objective: To report the experience of using rFVIIa in critically ill patients from the Intensive Care Unit (ICU) of The ABC Medical Center, Mexico City. Design: An observational, transversal and retrospective study from a database of 54 critically ill patients treated with rFVIIa in the ICU. Results: Etiology of bleeding: Surgical 50%, hematologic 22%, vascular 16.7%, multifactorial 11.3%, APACHE II 16.6 ± 6.5 (6-30), 22% of total patients were infected, general mortality of 35.2%, amount of doses necessaries to stop bleeding: Survivors: 336 mL/h pre dose and 45 mL/h post dose, Non survivors: 290 mL/h pre dose and 66 mL/h post dose. Conclusion: Administration of rFVIIa in critically ill patients was coincidental with a lowering rate of bleeding.


REFERENCES

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