2003, Number 1
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Rev Biomed 2003; 14 (1)
Chagas' disease in the state of Yucatan, Mexico (1940-2002)
Zavala-Velázquez JE
Language: Spanish
References: 26
Page: 35-43
PDF size: 45.66 Kb.
ABSTRACT
The first evidence of Chagas' disease in Yucatan appeared in 1940, but it was not until 1972 that the first investigation was carried out on this disease. This study demonstrated a serological prevalence of 11.2%, and found 12 clinical cases. In this study the vectors (triatoma) found had a prevalence of infection for
T. cruzi of 17.3%. Nineteen years later the prevalence in vectors continued to be similar (16%), but for the first time a high index of colonisation was detected and a year later it was shown that among the biological habits of triatoma the human had moved to first place from the fourth place it had occupied fifteen years earlier. In 1985, another study showed that the seroprevalence had increased to 18%.
During the 1990s two studies carried out on blood donors showed the possibility of blood transfusions being a risk of infection. Studies carried out recently have allowed us to determine that temperature has a preponderant role in the transmission capacity of the triatoma and that the strains found in Yucatan are philogenetically different to those from the rest of the country. The panorama of the protean mitochondrial componantes of
T. cruzi has been completed giving posibilities of identifying potential targets for the investigation into therapeutic drugs. In this study, it is demonstrated how knowledge achieved over time can contribute to the solution of health problems affecting a population and how investigation allows for the development of new knowledge.
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