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Centro de Investigaciones Regionales Dr. Hideyo Noguchi, Universidad Autónoma de Yucatán

2004, Number 3

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Rev Biomed 2004; 15 (3)

Lupus erythematosus: systemic autoimmune and organ specific disease

Sánchez-Rodríguez SH, Barajas-Vásquez GE, Ramírez-Alvarado ED, Moreno-García A, Barbosa-Cisneros OY

Language: Spanish
References: 38
Page: 173-180
PDF size: 92.15 Kb.


ABSTRACT

The immune system of patients with Lupus becomes activated and reacts against themselves, which is why it is considered an autoimmune disease. In the USA more than one million people have Lupus. The symptoms appear in a variety of forms, and half of the cases are lethal. The damage may appears in any organ of the body and can cause arthritis with inflammation, fatigue, facial o malar rash, oral ulcers, photosensitivity, serositis (inflammation of tissue around the lung and heart), renal disorders (proteinuria, cellular destruction), blood disorders (leukopenia, lymphopenia, thrombocytopenia, hemolytic anemia), immunological disorders (anti-DNA, anti-Sm antibodies), and abnormal antinuclear antibody titles.
Using molecular biology techniques some factors that regulate the immune system and biochemistry mechanisms of tissues damage in lupus have been discovered. In addition some genes that appear to be involved in the generation of lupus have been identified.


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