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Instituto Nacional de Perinatología

2002, Number 1

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Perinatol Reprod Hum 2002; 16 (1)

Ruptura prematura de las membranas corioamnióticas. Valor predictivo del estado de nutrición en vitamina C y la infección

Pfeffer F, Lobatón R, Reyes L, Luna A, Narcio L, Casanueva E

Language: Spanish
References: 25
Page: 4-9
PDF size: 115.36 Kb.


ABSTRACT

Objective: To validate the relation between vitamin C nutrition status and cervicovaginal infections during pregnancy with the subsequent occurrence of PROM found in previous studies.
Material and methodology: Eighty-two pregnant women who attended the prenatal care clinic at the Instituto Nacional de Perinatologia in Mexico City were followed every four weeks during gestation starting at week 16 of pregnancy until one month postpartum. A vaginal smear for the diagnosis of infections was taken on every appointment as well as a 10 mL blood sample to determined plasma and leukocyte vitamin C concentrations.
Results: Nineteen women had PROM (0.23 of the studied women). No relation was found on plasma ascorbic acid concentrations, type or frequency of infections with PROM. These women had lower leukocyte concentrations at weeks 24 and 28 of gestation. At week 28 leukocyte vitamin C concentration cut-off point with prognostic value for PROM was 16.9 µg/108 cells (odds ratio 4.03, C.I. 1.38 - 11.8). Women with PROM persisted with lower leukocyte vitamin C concentrations at one month postpartum for a cut-off point of 26.5 µg/108 cells.
Conclusions: No relation was found between cervicovaginal infections, vitamin C concentrations and PROM, however, low leukocyte vitamin C concentrations at week 28 of pregnancy were related to a higher PROM risk. Women with PROM seemed to recover their leukocyte vitamin C concentrations slower than the ones without PROM.


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