medigraphic.com
ISSN 0187-5337 (Print)
Instituto Nacional de Perinatología

2003, Number 2

<< Back Next >>

Perinatol Reprod Hum 2003; 17 (2)

Presencia de los marcadores serológicos de autoinmunidad en mujeres con embarazo complicado con preeclampsia

Baptista-González HA, Rosenfeld-Mann F, Vidal-González VM, Vargas-Trujillo S, Trueba-Gómez R

Language: Spanish
References: 28
Page: 72-79
PDF size: 143.84 Kb.


ABSTRACT

Objective: To describe the association between anticardiolipin antibodies (ACA) and antinuclear antibodies (ANA) in women with low risk pregnancy or complicated with preeclampsia. Material and methods: We selected no pregnant to healthy women (group control), women with low risk pregnancy and patients with preeclampsia. We studied the serologic status of ACA and ANA. Results: We included 433 women, 231, 151 and 51 cases for each group, respectively. The global prevalence of ACA and ANA was 1.8% and 15.2%. The cases of ACA, were distributed in 7 (3.0 %), 1 case (0.7 %), in the group healthy control and pregnant healthy women, respectively. There were no ACA positive cases in patients with preeclampsia. The global prevalence of anti-ssDNA, anti-RnP, anti-SSA, ant-SSB, and anti-histone was of 8.7, 0,5, 4.6, 3.9, 0.5 %, respectively. We no detected cases with ant-Scl70. Discussion: We didn’t document the greater presence of the ACA in patients with preeclampsia. There is not association between ACA and ANA. Both tests are independent events related to preeclampsia.


REFERENCES

  1. Mekel PA, Chang Y, Pierangeli SS, Covery, Harris EN, Polisson RP. The prevalence and clinical associations of anticardiolipin antibodies in a large inception cohort of patients with connective tissue diseases. Am J Med 1996; 101: 576-83.

  2. Parke A, Majer D, Hakim C, Randolph J, Andreoli J. Subclinical autoimmune disease and recurrent spontaneous abortion. J Rheumatol 1986; 13: 1178-80.

  3. Yasuda M, Takakuwa K, Tokunaga A, Tanaka K. Prospective studies of the association between anticardiolipin antibody and outcome of pregnancy. Obstet Gynecol 1995; 86: 555-9.

  4. Fialova L, Mikuiokova L, Matous MI, Benesova O, Zwinger A. Prevalence of various antiphospholipid antibodies in pregnant woman. Physiol Rev 2000; 49: 299-305.

  5. Sletnes KE, Wisloff F, Moe N, Dale PO. Antiphospholipid antibodies in pre-eclamptic women: relation to growth retardation and neonatal outcome. Acta Obstet Gynecol Scand 1992; 71: 112-7.

  6. Milliez J, Lelong F, Bayani N, Jannet D, Medjadji El, Lastrous H, et al. The prevalence of autoantibodies during third-trimester pregnancy complicated by hypertension or idiopathic fetal growth retardation. Am J Obstet Gynecol 1991; 165: 51-6.

  7. Shaarawy M, El Meleigy M, Rasheed K. Maternal serum transforming growth factor beta-2 in preeclampsia and eclampsia, a potential biomarker for the assessment of disease severity and fetal outcome. J Soc Gynecol Investig 2001; 8: 27-31.

  8. Dreyfus M, Hedelin G, Kutnahorsky R, Lehenann M, Viville B, Langer R, et al. Antiphospholipid antibodies and preeclampsia: a case control study. Obstet Gynecol 2001; 97: 29-34.

  9. Kochenour NK, Branch DW, Rote NS, Scott JR. A new postpartum syndrome associated with antiphospholipid antibodies. Obstet Gynecol 1987; 69: 460-8.

  10. Out HJ, Bruinse HW, Godelieve C, van Vliet M, de Groot PG, Nieuwenhuis HK, et al. A prospective, controlled multicenter study on the obstetric risk of pregnant women with antiphospholipid antibod ies. Am J Obstet Gynecol 1992; 167: 26-32.

  11. Uncu H, Ozan H, K¨¹c¨¹kerdogan I, Cenigz C. Anticardiolipin antibodies in pregnancy induced hypertension. Eur J Obstet Gynecol 1996; 70: 97-100.

  12. Matthiesen LS, Berg G, Ernerudh J, Skogh T. A prospective study on the occurrence of autoantibodies in low-risk pregnancies. Eur J Obstet Gynecol 1999; 83: 21-6.

  13. El-Roeiy A, Myers SA, Gleicher N. The prevalence of autoantibodies and lupus anticoagulant in healthy pregnant women. Obstet Gynecol 1990; 75: 390-6.

  14. Ober C, Karrison T, Harlow L, Elias S, Gleicher N. Autoantibodies and pregnancy history in a healthy population. Am J Obstet Gynecol 1993; 169: 143-7.

  15. North RA, Taylor RS, Schellenber JC. Evaluation of a definition of pre-eclampsia. Br J Obstet Gynaecol 1999; 106: 767-73.

  16. ACOG Committee on Obstetric Practice. ACOGH practice bulletin. Diagnosis and management of preeclampsia and eclampsia. American College of Obstetrician and Gynecologist. Int J Gynecol Obstet 2002; 77: 67-75.

  17. Branch DW, Porter TF, Rittenhouse L, Caritis S, Sibai B, Hogg B, et al. Antiphospholipid antibodies in women at risk for preeclampsia. Am J Obstet Gynecol 2001; 184: 825-32.

  18. Mart¨ªnez AE, Gonz¨¢lez OM, Cortes LLV, Salazar PM. Anticardiolipin antibodies and the severity of preeclampsia-eclampsia. Gynecol Obstet Invest 1999; 48: 168-71.

  19. Takakua H, Honda K, Ishii K, Hataya I, Masako Y, Tanaka K. Studies on the HLADRB1 genotypes in Japanese women with severe pre-eclampsia positive and negative for anticardiolipin antibody using PCRRFLP method. Hum Reprod 1999; 14: 2980-6.

  20. Valdes ME, Cabiedes J, Villa AR, Cabral AR, Alarc¨®n SD. Anticardiolipin and antibeta2- glycoprotein-I antibodies in hypertensive disorders of pregnancy. Arch Med Res 2002; 33: 460-5.

  21. Katano K, Aoki K, Sasa H, Ogasawara M, Matsuura E, Yagami Y. ¦Â2-glicoprotein Idependent anticardiolipin antibodies as a predictor of adverse pregnancy outcomes in healthy pregnant women. Hum Reprod 1966; 11: 509-12.

  22. Baptista GHA, Rosenfeld MF. Changes in the thrombophilic status in patients with preeclampsia. Ginecol Obstet Mex 1999; 67: 176-82.

  23. Alfirevic Z, Martlew W. How strong is the association between maternal thrombophilia and adverse pregnancy outcome? A systematic review. Eur J Obstet Gynecol Reprod Biol 2002; 101: 6-14.

  24. Conde AA, Belizan JM. Risk factors for pre-eclampsia in a large cohort of Latin American and Caribbean women. Br J Obstet Gynecol 2000; 107: 75-83.

  25. Yamamoto T, Yoshimura S, Geshi Y, Sasamori Y, Mori H, Kobayashi T. AntissDNA and dsDNA antibodies in preeclampsia. Asia Oceania J Obstet Gynecol 1994; 20: 93-9.

  26. Harris EN, Gharavi AE, Boey ML, Patel BM, Mackworth CG, Loizou S, et al. Anticardiolipin antibodies detection by radioimmunoassay and association with thrombosis in systemic lupus erythematosus. Lancet 1983; 8361: 1211-4.

  27. 27.Watson RM, Braunstein BL, Watson AJ, Hochberg MC, Provost TT. Fetal wastage in women with anti-Ro(SSA) antibody. J Rheumatol 1986; 13: 90-4.

  28. Lunderberg I, Hedfors E. Pregnancy outcome in patients with high titer anti-RnP antibodies. A retrospective study of 40 pregnancies. J Rheumatol 1991; 18: 359-62.




2020     |     www.medigraphic.com