Romero-Maldonado S, Blaz-Rodríguez AU, Ascencio-Mujica BM, Villalobos-Alcazar BG, López-Barrera AMD

Language: Spanish
References: 38
Page: 133-145
PDF size: 194.49 Kb.

ABSTRACT

Objective: Determinate morbidity and mortality perinatal risk of neonates born to mothers with preeclampsia, compared with neonates born to healthy mothers. Methodology: This is a retrospective, comparative cohort. We analyzed 1,178 files in a third level hospital from January 1st, 2000 to December 31st, 2001. There were 589 neonates born to mothers with diagnosis of preeclampsia (cases) and 589 of healthy mothers (controls), matched by gestational age. We analyzed maternal and neonatal variables for morbidity and mortality. Statistics: Central tendency tests and dispersion were applied according to the variable. We determined the risk to get sick with relative risk (RR) with a confidence interval (CI) of 95%. The statistical significance was established with Student t test and χ2. To determine the effect of maternal treatment on the fetus we used logistic regression. Results: In relation to the severity of preeclampsia we found mild preeclampsia in 65.7% of cases, 23.2% in severe preeclampsia, 3.3% in eclampsia imminence, 2.7% eclampsia and 1.1% of HELLP syndrome. We found significative difference in the frequency of cesarean section and placental insufficiency in the case group. In relation to the neonatal variables, for the cases group, we found a higher relative risk for perinatal asphyxia, neurological alterations, hyperviscosity, thrombocytopenia, hypoglycemia and hypomagnesaemia. Specifically in the cases with less than 32 gestacional weeks of age, there was a higher relative risk with statistical significative difference for transient tachypnea of the newborn, intraventricular hemorrhage stages I and II, hyperviscosity, thrombocytopenia, hyponatremia and hypoglycemia. No significance for the rest of maternal and neonatal variables. Conclusions: Even though there is more understanding of the physiopathology of preeclampsia, the risk in the neonate to present metabolic, hematological and neurological alterations, persists yet.

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