lbarra VF, Vera MY, Hernández CA, Castillo BR

Language: English/Spanish
References: 25
Page: 297-301
PDF size: 454.78 Kb.

ABSTRACT

Fascioliscide activity of the compound 6-chloro 5-(1-naphtoxy)-2-methyltiobencimidazole, called alfa, was evaluated against four- and eight week-old flukes in sheep. Fifty crossbred sheep were used and infected each orally with 200 F. hepatica metacercariae. Four weeks postinfection, all animals were reinfected again with 200 metacercariae each. Eight weeks after the initial infection, when all animals were positive to Fasciola eggs, they were randomly divided into 5 groups of 10 sheep each. Groups 1 to 4 were treated orally with 10, 15, 22.2 and 30 mg/kg of compound alfa, respectively. Group 5 remained as the non-treated control. Two weeks after the treatment all sheep were euthanized in order to collect and count the flukes in the liver. Efficacy was determined as the percentage of fluke reduction in the treated groups in comparison to the control one. Results showed that at doses of 10, 15, 22.2 and 30 mg/kg of live weight, compound ALFA removed 4 weekold flukes in 82.2%, 87.2%, 90.8% and 94.3%, respectively; and 8 week-old flukes were removed in 81.7%, 88.1%, 87.2% and 90.0%, respectively. Average efficacy for both 4- and 8-week old stages was 82.0%, 87.6%, 89.2% and 92.4% for the four concentrations, respectively. It is concluded that the efficacy exerted by compound alfa was acceptable in terms of fascioliscide activity; being the dose of 15 mg/kg the most suitable one.

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