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Anales de Otorrinolaringología Mexicana

2004, Number 4

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Otorrinolaringología 2004; 49 (4)

Indometacina protege de los efectos del ozono sobre el sueño

MC Luxiola-González, Alfaro-Rodríguez A, Verduzco-Mendoza A, Escalante-Membrillo C, Bueno-Nava A, González-Piña R

Language: Spanish
References: 40
Page: 49-54
PDF size: 95.48 Kb.


ABSTRACT

Ozone (O3) exposure cause extrapulmonary effects, whose mechanisms are unclear, since O3 do not pass beyond the pulmonary tract. An involvement of prostaglandins (PG) and nitric oxide (NO), two molecules produced by reactions between O3 and the surfactant factor, has been proposed. In order to assay that hypothesis, we administrated indometacin (IND, 4 mg/kg), a PG and NO inhibitor, to eight male wistar rats exposed to 1 ppm of O3. Sleep was the extrapulmonary toxicity model employed; so, animals were implanted in order to record polygraphically sleep states. Sleep recordings were taken during 24 hours in every of the experimental conditions: 1. clean-air exposure; 2. IND + clean air; 3. 1 ppm of O3 exposure, and 4. IND + O3 exposure. It was found an increase of slow waves sleep and a concomitant decrease of paradoxical sleep when rats were exposed to O3. IND showed a protective effect mainly on paradoxical sleep. Regarding its role in sleep maintenance, results suggest that NO production and accumulation could be primarily involved in the extrapulmonary toxicity induced by O3 exposure


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