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1997, Number 3

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Vet Mex 1997; 28 (3)

Lung wet weight of diabetic rabbits subjected to a transthoracic challenge with the Klebsiella pneumoniae lipopolysaccharide

Nevárez GAM, Franco LRE, Cerda ACE, Rodríguez TLE, Niño FR, Ramírez RR

Language: English/Spanish
References: 23
Page: 247-250
PDF size: 379.41 Kb.


ABSTRACT

The purpose of this study was to evaluate the lung inflammatory response through histopathology and lung wetweight determinations in diabetic rabbits subjected to a challenge with Klebsiella pneumoniae lipopolysacharide (LPS). Two groups were included. Both groups received a transthoracic challenge with LPS directly into their right lungs. The left non-inoculated lungs were used as controls. Animals in Group 1 received the diabetogenic agent alloxan 110 days previously, whereas controls (Group 2) received saline solution. Five days after the challenge rabbits were euthanized. Histopathological examinations were similar in both groups however, lung wet weights showed that diabetic animals had a decreased lung inflammatory response compared to the control ones. These results agree with reports of deficiencies in the inflarnmatory response and repair mechanisms in diabetics.


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