Smit R, Salvarezza C, Buitrago C, Lespi P

Language: Spanish
References: 22
Page: 24-27
PDF size: 255.65 Kb.

ABSTRACT

Sarcomatoid carcinoma is a variant of metaplasic carcinoma. It is a rare tumor that can be mixed up with benign or atypical lesions and its diagnosis can be difficult to establish. We present a 39-years old woman case with three nodules in left breast. Surgical specimen showed a tumor composed by atypical spindle cells alternated with pleomorfic cells immersed in fibrous stroma. In the periphery of the lesion, ductal carcinoma was observed. We discussed the nomenclature, the differential diagnoses and the prognoses factors of a tumor that could have a more aggressive clinical course compared with the classic ductal carcinoma.

REFERENCES

1. Wargotz ES, Deos PH, Norris HJ. Metaplastic carcinomas of the breast. II. Spindle cell carcinoma. Hum Pathol 1989;20(8):732-40.

2. Patterson SK, Tworek JA, Roubidoux MA, Helvie MA, Oberman HA. Metaplastic carcinoma of the breast: mammographic appearance with pathologic correlation. AJR Am J Roentgenol 1997:169(3): 709-12.

3. Pellicer EM, Gómez Rueda N, Sundblad AS, et al. Carcinoma metaplásico de la mama. Revisión de 17 casos con estudio inmunohistoquímico. Patología (Méx) 1995;33:71-75.

4. Borowsky AD, Gobbi H. Metaplastic carcinoma of the breast:grading and behavior of predominantly spindle cell tumors. Pathology Case Reviews 1999;4:208-13.

5. Wargotz ES, Norris HJ. Metaplastic carcinoma of the breast.I. Matrix-producing carcinoma. Hum Pathol 1998;20(7):628-35.

6. Gobbi H, Simpson JF, Borowsky A, Jensen RA, Page DL.Metaplastic breast tumors with a dominant fibromatosislike phenotype have a high risk of local recurrence. Cancer 1999;85(10):2170-82.

7. Al-Nafussi A. Spindle cell tumors of the breast: practical approach to diagnosis. Histopathology 1999;35(1):1-13.

8. Kaufman MW, Mart JR, Gallager HS, Hoehn JL. Carcinoma of the breast with pseudosarcomatous metaplasia. Cancer 1984;53(9):1908-17.

9. Amillano PK, Rezola SR, Alberro AJA, Elorriaga BK, Martín LA, Plazaola AA. Carcinoma metaplásico de mama. Revisión a propósito de un caso. Oncología 2004;27(9):42-46.

10. Pérez Mies B, Crespo CM, Echeverría IC, Claver CM, Tello RA. Carcinoma sarcomatoide monofásico de mama “fibromatosis- like”. A propósito de un caso y revisión de la literatura. Patología (Esp) 2004;37(4):411-4.

11. Bauer TW, Rostock RA, Eggleston JC, Baral E. Spindle cell carcinoma of the breast: four cases and review of the literature. Hum Pathol 1984;15(2):147-52.

12. Wargotz ES, Norris HJ. Metaplastic carcinomas. III. Carcinosarcoma.Cancer 1989;64(7):1490-9.

13. Wargotz ES, Norris HJ. Metaplastic carcinomas of the breast. IV. Squamous cell carcinoma of ductal origin. Cancer 1990;65(2):272-6.

14. Wargotz ES, Norris HJ. Metaplastic carcinoma of the breast: V. Metaplastic carcinoma with osteoclastic giant cells. Hum Pathol 1990;21(11):1142-50.

15. Gersell DJ, Katzenstein AL. Spindle cell carcinoma of the breast. A clinicopathologic and ultrastructural study. Hum Pathol 1981;12(6):550-61.

16. Rosen PP. Patología mamaria de Rosen. 2a ed. Bogotá: AMOLCA, 2005.

17. Brenner RJ, Turner RR, Schiller V, Arndt RD, Giuliano A.Metaplastic carcinoma of the breast: report of three cases. Cancer 1998;82(6):1082-7.

18. Tavassoli FA. Myoepithelial lesions of the breast. Myoepitheliosis,adenomyoepithelioma, and myoepithelial carcinoma. Am J Surg Pathol 1991;15(6):554-68.

19. Weidner N, Levine JD. Spindle-cell adenomyoepithelioma of the breast. A microscopic, ultrastructural, and immunocytochemical study. Cancer 1988;62(8):1561-7.

20. Toikkanen S. Primary squamous cell carcinoma of the breast.Cancer 1981;48(7):1629-32.

21. Battifora H. Spindle cell carcinoma. Ultrastructural evidence of squamous origin and collagen production by the tumor cells. Cancer 1976;37(5):2275-82.

22. Rosen PP, Ernsberger D. Mammary fibromatosis. A benign spindle-cell tumor with significant risk for local recurrence. Cancer 1989;63(7):1363-9.