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Colegio de Medicina Interna de México.

2008, Number 4

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Med Int Mex 2008; 24 (4)

Metabolic syndrome in México

Carranza MJ, López CSM

Language: Spanish
References: 22
Page: 251-261
PDF size: 311.59 Kb.


ABSTRACT

Background: Metabolic syndrome is a public health problem in Mexico; insulin resistance and endothelial dysfunction are its most recognized physiopathogenic features, and it increases diabetes and cardiovascular events risk.
Objective: To determine the frequency of insulin resistance and endothelial dysfunction in patients with metabolic syndrome, and to report their metabolic, vascular and mood characteristics.
Patients and method: A consecutive sample of 181 patients diagnosed with metabolic syndrome according to National Cholesterol Education Program criteria; insulin resistance was evaluated by means of Homeostasis Model Assessment, endothelial function by flow-dependent vasodilatación in brachial artery, intimal to medial carotid thickness by ultrasound, and depression by means of Beck inventory.
Results: From 181 patients, 101 had metabolic syndrome, and 80 had not. From those who had it, 57.4% had resistance to insulin and 34.4% endothelial dysfunction. Most frequent components of syndrome were: Central obesity, high blood pressure and hypertriglyceridaemia. Central adiposity, alterations of glucose metabolism and depression prevailed in women; and hypertension and vascular damage in men. Insulin resistance was associated with a higher frequency of all syndrome elements, especially central obesity, but not with high blood pressure neither high cholesterol levels.
Conclusions: Insulin resistance frequency in metabolic syndrome was smaller than expected, but its presence is associated with high frequency of metabolic and vascular alterations and depression.


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