Cabrera RA, Laguna HG, López HG, Villagómez OA, Méndez RR, Guzmán GR

Language: Spanish
References: 10
Page: 38-42
PDF size: 120.69 Kb.

ABSTRACT

Few spaces exist in critical medicine that have woken up so much interest, investigation and frustration as sepsis. In spite of the advances in diagnostic and therapeutic methods, the morbidity and mortality keep on being unacceptably elevated. Sepsis is the systemic reaction exaggerated of the guest to the infection that alters the homeostasis through a waterfall gone out of control of inflammation, immunosuppression, upsets in the coagulation and the fibrinolysis’ alteration. Damage provokes hipoxia to microcirculation and direct damage to the tissues that usually leads patients to shock, multiple organic dysfunction and death. This paper includes the main physiopathological mechanisms of host response to pathogen microorganisms invasion, including proinflammatory cytokines release, immunosuppression, coagulation cascade affection and the importance of genetic susceptibility to sepsis.

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