2008, Number 39
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Med Univer 2008; 10 (39)
Fetal programming of adulthood diseases
Martínez VLE
Language: Spanish
References: 16
Page: 108-113
PDF size: 172.08 Kb.
ABSTRACT
The purpose of the present review is to summarize some of the intrauterine factors implicated on the person’s development during neonatal and fetal life producing the concept of “fetal programming of adult diseases”. This is an analysis of the role of maternal nutrition and intrauterine growth restriction as risk factors for type 2 diabetes mellitus, obesity, coronary heart disease, hypertension and the epigenetic mechanisms that interact with gene expression during development, establishing the set points of physiological processes that will regulate adult functions.
REFERENCES
Rogers JM, Kavlock RJ. Developmental toxicology. In: Klaassen CD, editor. Toxicology. The basic science of poisons. 1st ed. New York: McGraw-Hill, 1996;pp:310-31.
Botto LD, Moore CA, Khoury MJ, Ericksson JD. Neural tub defects. N Eng J Med 1999;341:1509-19.
Hall JG. The importance of the fetal origin of adult disease for geneticists. Clin Genet 2007;72:67-72.
Jirtle RL, Skinner MK. Environmental epigenomics and disease susceptibility. Nat Rev Genet 2007;6:253-62.
Barker DJ, Hales CN, Fall CH, Osmond C, et al. Type 2 (non- insulin dependent) diabetes mellitus, hypertension and hyperlipidaemia (syndrome X): relation to reduced fetal growth. Diabetologia 1993;36:62-67.
Sinclair KD, Lea RG, Rees WD, Young LE. The developmental origins of health and disease: current theories and epigenetic mechanisms. Soc Reprod Fertil Suppl 2007;64:425-43.
Gicquel C, El-Osta A, Le Bouc Y. Epigenetic regulation and fetal programming. Best Pract Res Clin Endocrinol Metab 2008;22:1-16.
Lau C, Rogers JM. Embryonic and fetal programming of physiological disorders in adulthood. Birth Defects Res C Embryo Today 2004;72:300-12.
Lee HK, Park KS, Deng JH, Cho YM, et al. Mitochondria based model for fetal origin of adult diseases and insulin resistance. Ann NY Acad Sci 2005;1042:1-18.
Nafee TM, Farrell WE, Carroll WD. Fryer AA, Ismail KM. Epigenetic control of fetal gene expression. BJOG 2008;115:158-68.
Sinclair KD, Lea RG, Rees WD, Young LE. The developmental origins of health and disease: current theories and epigenetic mechanisms. Soc Reprod Fertil Suppl 2007;64:425-43.
Reik W, Dean W, Walter J. Epigenetic reprogramming in mammalian development. Science 2001;293:1089-93.
Mathers JC. Early nutrition: impact on epigenetics. Forum Nutr 2007;60:42-48.
Luo ZC, Fraser WD, Julien P, Deal CL, Walker M. Tracing the origins of “fetal origins” of adult diseases: programming by oxidative stress? Med Hypotheses 2006;66:38- 44.
Fernandez Twinn DS, Ozanne SE. Mechanisms by which poor early growth programs type-2 diabetes, obesity and the metabolic syndrome. Physiol Behav 2006;88:234- 43.
Kajantie E. Fetal origins of stress-related adult disease. Ann NY Acad Sci 2006;1083:11-27.