Santos-Martínez LF, Zúñiga-Vega MA, Aranda A, Quiroz A, Meave A, Castañón A, Rojas G, Verdejo J

Language: Spanish
References: 32
Page: 48-54
PDF size: 105.30 Kb.

ABSTRACT

Thymomas are primary tumors that arise from the epithelial cells of the thymus. Frequently, they are found in the anterior mediastinum, associated to a parathymic syndrome. Although they may stay asymptomatic, they may also give rise to unspecific clinical manifestations, which include chest pain, dyspnea, and cough, symptoms that generally disappear with surgical resection of the thymoma. In these cases, incidental diagnosis is usually established by using various image methods that may include chest X-ray, computed tomography, and magnetic resonance, and it is confirmed by tumor biopsy. Survival depends on Masaoka’s clinical stage, the size of the tumor, the type of resection performed and the histological subtype. Complete surgical resection is the main objective. The use of pre and/or postoperatory chemo and/or radiotherapy is still controversial. We present the case of a woman who suffered from a myocardial infarction. She was later incidentally diagnosed with a right paracardiac tumor that came out to be a thymoma.

REFERENCES

1. . Morgenthaler T, Brown L, Colby T, Harper C, Coles D. Thymoma. Mayo Clin Proc 1993; 68:1110-1123.

2. Strollo DC, Rossado ML, Jett JR. Primary mediastinal tumors. Part 1. Tumors of the anterior mediastinum. Chest 1997;112: 511-522.

3. Ibarra-Pérez C, Kelly-García J, Fernández-Corzo MA. Guía diagnóstico-terapéutica: tumores y masas del mediastino. Rev Inst Nal Enf Resp Mex 2001;14:172-177.

4. Clavijo-Montecinos I, Criales JL. Timoma no invasor. Gac Méd Méx 2001;137:485-486.

5. Barón Esquivias G, Ordóñez A, Mayol A, Gavilán F. Timoma paracardiaco izquierdo. Rev Esp Cardiol 2001;54:643-644.

6. Paul DE, Graham J, Forgetta J, Turissi T, Saidman B. Detection of occult thymoma during exercise thallium 201, technetium 99m tetrafosmin imaging for coronary artery disease. Chest 2000;118:550-551.

7. Maticke GJ, Sokol JA, Jozwiak J, Ruisi J. Detection of thymoma by SPECT thallium imaging. J Nucl Cardiol 1998;5:449-450.

8. Hitoya O, Tetsuo T, Hiroyoshi W, Tomoo K, Masaharu N, Keijiro K. Tl-201 and Tc-99m HMPAO SPECT in a patient with recurrent thymoma. Clin Nucl Med 1996;21:902-903.

9. Campeau RJ, Ey EH, Varma DGK. Thallium-201 uptake in a benign thymoma. Clin Nucl Med 1986;11:524.

10. Adalet I, Kocak M, Ece T. Tc99m MIBI and Tl-201 uptake in a benign thymoma. Clin Nucl Med 1995;20:733-734.

11. Abdullah F. An incidental finding of thymic carcinoid during urgent CABG operation. Heart Surg Forum 2002;5:35-36.

12. Kojima K, Yyokoi K, Matsuguma H, et al. Middle mediastinal thymoma. J Thorac Cardiovasc Surg 2002;124:639-640.

13. Ishibashi H, Takahashi S, Hosaka T, Shibuya J, Suzuki S, Handa M. Primary intrapulmonary thymoma successfully resected with vascular reconstruction. Ann Thorac Surg 2003;76:1735-1737.

14. Blaker H, Dragoje S, Laissue JA, Otto HF. Pericardial involvement by thymomas. Entirely intrapericardial thymoma and a pericardial metastasis of thymoma with glomeruloid vascular proliferations. Pathol Oncol Res 1999;5:160-163.

15. Oh YL, Ko YH, Ree HJ. Aspiration cytology of ectopic cervical thymoma mimicking a thyroid mass: a case report. Acta Cytol 1998;42:1167-1171.

16. Fushimi H, Tanio Y, Kotoh K. Ectopic thymoma mimicking diffuse pleural mesothelioma: a case report. Human Pathol 1998;29:409-410.

17. Singh-Sidhu U, Malhotra V, Singh-Chhina G. An unusual case of pseudocardiomegaly. Chest 1998;113:1711-1714.

18. Carr CS, O´Keffe PA. An ectopic thymoma with spontaneous infarction. J Thorac Cardiovasc Surg 2001;122:1234-1235.

19. Gray KM, Windsor M. Thymoma presenting with infarction. Heart Lung Circ 2004;13:191-194.

20. Cañizares MA, Arnau A, Alberola A, et al. Timomas. Estudio retrospectivo. Arch Bronconeumol 1999; 35:324-328.

21. Abad C. Tumores cardiacos (II). Tumores primitivos malignos. Tumores metastásicos. Tumor carcinoide. Rev Esp Cardiol 1998;51:103-114.

22. Salyer WR, Eggleston JC. Thymoma: A clinical and pathological study of 65 cases. Cancer 1976;37:229-249.

23. Egea AM, Albasini JLA, Paricio PP, Pérez JS, Lax FG, Bascunana AJ. Prognostic factors of thymoma. Eur J Surg Oncol 1995;21:482-485.

24. Gawrychowsky J, Rokicki M, Gabriel A, Lackowska B, Czyzewski D. Thymoma-the usefulness of some prognostic factors for diagnosis and surgical treatment. Eur J Surg Oncol 2000;26:203-208.

25. Kondo K, Yoshizawa K, Tsuyuguchi M, et al. WHO Histologic classification is a prognostic indicator in thymoma. Ann Thorac Surg 2004;77:1183-1188.

26. Nakagawa K, Asamura H, Matsuno Y, et al. Thymoma: A clinicopathologic study based on the new World Health Organization classification. J Thorac Cardiovasc Surg 2003;126:1134-1140.

27. Kondo K, Monden Y. Therapy for thymic epithelial tumors: A clinical study of 1320 patients from Japan. Ann Thorac Surg 2003;76:878-885.

28. Waller BF. Nonatheroesclerotic coronary heart diseases. In: Wayne AR, Schlant RC, Fuster V, editors. Hurst´s the heart. USA: McGraw-Hill; 1998.p.1197-1240.

29. Cheitlin MD, McAllister GA, de Castro CM. Myocardial infarction without atherosclerosis. JAMA 1975;231:951-955.

30. Ammann P, Marschall S, Kraus M, et al. Characteristics and prognosis of myocardial infarction in patients with normal coronary arteries. Chest 2000;117: 333-338.

31. Mittleman MA, Maclure M, Tofler GH. and The Determinants of Myocardial Infarction Onset Study Investigators. Triggering of acute myocardial infarction by heavy physical exertion. N Engl J Med 1993;329:1677-1683.

32. Isner JM, Estes NA, Thompson PD. Acute cardiac events temporally related to cocaine abuse. N Engl J Med 1986;315:1438-1443.