Menezes N, Varela P, Furtado A, Mota G , Baptista A

Language: English
References: 29
Page: 252-255
PDF size: 214.57 Kb.

ABSTRACT

Linear IgA dermatosis is an auto-immune bullous disease characterized by linear IgA deposition in the basement membrane. Most cases are idiopathic but some are drug-related. These lack mucosal involvement, have spontaneous remission and IgA deposition clearance at the basement membrane after drug cessation. A 89 year-old patient presenting with symmetric, itchy, tense and translucent bullous lesions located on the upper limbs and abdomen with 2 weeks evolution is reported. The patient had started captopril regimen two months before. The diagnosis was histologically confirmed. The patient started prednisolone and changed the hypertension medication from captopril to amlodipine. After 4 weeks an almost complete resolution of the lesions was observed. Prednisolone was slowly tapered and there have been no relapses for almost 2 years. Skin autoimmune diseases are almost always idiopathic. However some cases can be induced or aggravated by exogenous factors including drugs, trauma, infections, vaccinations, radiographs and UV radiation[1]. Linear IgA bullous dermatosis (LABD), a rare, acquired, autoimmune, heterogeneous subepidermal blistering disorder, is no exception[2]. Patients may present with combinations of annular or grouped papules, vesicles, and bullae. Typically, these lesions are distributed symmetrically on extensor surfaces including elbows, knees, and buttocks[2].

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