Rosas TAG, Arce MAY

Language: Spanish
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Page: 5-7
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ABSTRACT

Mycobacterium tuberculosis is a causative agent of tuberculosis, which is a significant health problem.Host’s defense mechanisms are located in the respiratory tract, where molecules like lysozyme, lactoferrin, defensins, cathelicidins and surfactant proteins are important in the tuberculosis control. In the tuberculosis infection is necessary the interaction between Mycobacterium tuberculosis with pattern-recognition receptors expressed on macrophages’ surface that favoring the entry of Mycobacterium tuberculosis into the cell and cytokines production. Proinflammatory cytokines like IL-1, TNF-a, IL-12, and IL-8 play an important role in early stage of infection. IL-12 and IFN-g (Th1 cytokine) are important in CD4 T cell and macrophage activation. Inflammatory process in tuberculosis is immunoregulated by IL-10 and TGFb cytokines, it is important for host’s survival, but it immunoregulation must permit a balance between inflammatory and immunoregulatory cytokines and avoid the immune system suppression that favoring the multiplication of mycobacteria. Susceptible or resistant biomarkers to tuberculosis disease have been extensively studying, but all them have been focus in MHC genes principally. Other genes associated with susceptible to tuberculosis diseases are NRAMP, vitamin D receptor and IFN-g receptor.