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Colegio de Medicina Interna de México.

2007, Number 6

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Med Int Mex 2007; 23 (6)

Hepatitis C and pregnancy

García FWO, López MJ

Language: Spanish
References: 64
Page: 524-531
PDF size: 150.09 Kb.


ABSTRACT

The pregnancy implies an important variation estimulated by sexual hormones human physiology. These changes can originate diseases that secondarily affect the liver, like the gravidic hiperemesis, HELLP syndrome, intrahepatic colestasis and the acute hepatic esteatosis of the pregnancy. The liver is, perhaps, the main catabolic, detoxificadoras, digestive and immunological organ that regulates the physiology human, because it participates in biosintetics functions. Its primary or secondary alteration determines the appearance of the hepatics diseases, independently of its cause. The acute course of the viral hepatitis does not represent problems clinical during the pregnancy. The hepatitis that originate important problems during the pregnancy are caused by the virus and and the simple virus herpes. Hepatitis C during the pregnancy represents a medical challenge for their treatment. The disease does not interfere with the pregnancy, childbirth or health of the mother and newborn. The drug administration by intravenous route is the main factor of risk to contract hepatitis C (positive women to antiVHC). Other factors include: sanguineous transfusions, parenteral exhibition during the operations or estomatological cares, corporal application of piercing or tattoos. The pregnancy does not affect the evolution of hepatitis C, because the concentrations of aminotransferases diminished during the pregnancy, but the VHC-ARN titles are increased. Until the moment the antiviral agents are teratogenics (ribavirin) or produce adverse effects in the fetal growth (interferon). The transmission of the virus is prepared by exhibition prophylactic, similar to the strategy of hepatitis B; nevertheless, not yet vaccines against hepatitis C are developed and the inmunoglobulina is ineffective to prevent it.


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