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2007, Number 6

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Acta Pediatr Mex 2007; 28 (6)

Neonatal uricosuria and its relation with maternal uricemia

Medina-Escobedo M, Sánchez-Buenfil G, Salha-Villanueva J, Medina-Escobedo C, Gala-Trujano E

Language: Spanish
References: 15
Page: 248-252
PDF size: 120.69 Kb.


ABSTRACT

Introduction: Some studies have shown hyperuricosuria in healthy newborns in the state of Yucatan, Mexico. For this reason it was found necessary to determine the origin of this problem.
Objective: To know the relationship between maternal uricemia and blood and urinary uric acid levels in newborns.
Methods: After approval by the Hospital Research Ethics Committee a correlation study was done in 67 apparently healthy mother-child binomials. Blood uric acid (bUA) and glomerular filtration corrected urinary uric acid (GFuUA) – uricosuria – were determined for mothers (M) and their newborns (NB). A Spearman correlation test was done to determine the relation between the variables. Sample size was calculated using values of r = 0.3, α = 0.05 and Β = 0.20, with a significance value of p ‹ 0.05.
Results: MbUA = 4.84 ± 0.97 mg/dL; NBbUA = 5.03 ± 1.06 mg/dL; MGFuUA = 0.56 ± 0.18 mg/dL; NBGFuUA = 2.56 ± 0.84 mg/dL. The correlation tests showed rs = 0.34 (p = 0.005) for MbUA:NBbUA; rs = 0.12 (p = 0.33) for MbUA:NBGFuUA; and rs = 0.15 (p = 0.22) for NBbUA:NBGFuUA.
Conclusions: Only 13% of uricemia in newborns was related to maternal uricemia and the latter had no relation to uricosuria in newborns. Uricosuria in neonates was higher than levels reported previously.


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