Acevedo RCG, Álvarez E, Zafra RG, Álvarez NM, Gariglio P

Language: Spanish
References: 41
Page: 205-213
PDF size: 290.03 Kb.

ABSTRACT

Microarray technology has remarkably accelerated the understanding of the molecular events of neoplasias. By means of gene expression profiles, a molecular subclassification of cancer patients and the identification of thousand of genes involved in this pathology have been achieved. Herein, the general use of DNA microarrays in cervical cancer tumorigenesis is reviewed. Finally, putative molecular tumour markers as useful factors in diagnosis, prognosis, and tailor-made therapy for this disease are proposed.

REFERENCES

1. Walboomers JM, Jacobs MV, Manos MM, Bosch FX, et al. Human papillomavirus is a necessary cause of invasive cervical cancer worldwide. J Pathol 1999;189:12-19.

2. Garcia-Carranca A, Gariglio PV. Molecular aspects of human papillomaviruses and their relation to uterine cervix cancer. Rev Invest Clin 1993;45:85-92.

3. International Human Genome Sequencing Consortium. Finishing the euchromatic sequence of the human genome. Nature 2004;431:931-45.

4. Schena M, Shalon D, Davis RW, Brown PO. Quantitative monitoring of gene expression patterns with a complementary DNA microarray. Science 1995;270:467-70.

5. Lockhart DJ, Dong H, Byme MC, Follettie MT, et al. Expression monitoring by hybridization to high-density oligonucleotide arrays. Nat Biotechnol 1996;14:1675-80.

6. Wadlow R, Ramaswamy S. DNA microarrays in clinical cancer research. Curr Mol Med 2005;5:111-20.

7. Golub TR, Slonim DK, Tamayo P, Huard C, et al. Molecular classification of cancer: class discovery and class prediction by gene expression monitoring. Science 1999;286:531-7.

8. Alizadeh AA, Eisen MB, Davis RE, Ma C, et al. Distinct types of diffuse B-cell lymphoma identified by gene expression profiling. Nature 2000;403:503-11.

9. Rosenwald A, Wright G, Chan WC, Connors JM, et al. The use of molecular profiling to predict survival after chemotherapy for diffuse large B-cell lymphoma. N Engl J Med 2002;346:1937-47.

10. Shipp MA, Ross KN, Tamayo P, Weng AP, et all. Diffuse large Bcell lymphoma outcome prediction by gene expression profiling and supervised machine learning. Nat Med 2002;8:68-74.

11. Van’t Veer LJ, Dai H, Van de Vijver MJ, He YD, et al. Gene expression profiling predicts clinical outcome of breast cancer. Nature 2002;415:530-6.

12. Van de Vijver MJ, He YD, Van’t Veer LJ, Dai H, et al. A gene expression signature as a predictor of survival in breast cancer. N Engl J Med 2002;347:1999-2009.

13. Chang YE, Laiminis LA. Microarray analysis identifies interferon-inducible genes and Stat-1 as major transcriptional targets of human papillomavirus type 31. J Virol 2000;74:4174-82.

14. Nees M, Geoghegan JM, Munson P, Prabhu V, et al. Human papillomavirus type 16 E6 and E7 proteins inhibit differentiation-dependent expression of transforming growth factor-beta2 in cervical keratinocytes. Cancer Res 2000;60:4289-98.

15. Nees M, Geoghegan JM, Hyman T, Frank S, et al. Papillomavirus type 16 oncogenes downregulate expression of interferonresponsive genes and upregulate proliferation-associated and NF-kappaB-responsive genes in cervical keratinocytes. J Virol 2001;75:4283-96.

16. Duffy CL, Phillips SL, Klingelhutz AJ. Microarray analysis identifies differentiation-associated genes regulated by human papillomavirus type 16 E6. Virology 2003;314:196-205.

17. Garner-Hamrick PA, Fostel JM, Chien WM, Banerjee NS, et al. Global effects of human papillomavirus type 18 E6/E7 in an organotypic keratinocyte culture system. J Virol 2004;78:9041-50.

18. Toussaint-Smith E, Donner DB, Roman A. Expression of human papillomavirus type E6 and E7 oncoproteins in primary foreskin keratinocytes is sufficient to alter the expression of angiogenic factors. Oncogene 2004;23:2988-95.

19. Thomas JT, Oh ST, Terhune SS, Laimins LA. Cellular changes induced by low-risk human papillomavirus type 11 in keratinocytes that stably maintain viral episomes. J Virol 2001;75:7564-71.

20. Alazawi W, Pett M, Arch B, Scott L, et al. Changes in cervical keratinocyte gene expression associated with integration of human papillomavirus 16. Cancer Res 2002;62:6959-65.

21. Ruutu M, Peitsaro P, Johansson B, Syrjanen S. Transcriptional profiling of a human papillomavirus 33-positive squamous epithelial cell line which acquired a selective growth advantage after viral integration. Int J Cancer 2002;100:318-26.

22. Pett MR, Herdman MT, Palmer RD, Yeo GS, et al. Selection of cervical keratinocytes containing integrated HPV16 associates with episome loss and an endogenous antiviral response. Proc Natl Acad Sci USA 2006;103:3822-7.

23. Thierry F, Benotmane MA, Demeret C, Mori M, et al. A genomic approach reveals a novel mitotic pathway in papillomavirus carcinogenesis. Cancer Res 2004;64:895-903.

24. Wells SI, Aronow BJ, Wise TM, Williams SS, et al. Transcriptome signature of irreversible senescence in human papillomavirus-positive cervical cancer cells. Proc Natl Acad Sci USA 2003;100:7093-8.

25. Kelley ML, Keiger KE, Lee CJ, Huibregtse JM. The global transcriptional effects of the human papillomavirus E6 protein in cervical carcinoma cell lines are mediated by the E6AP ubiquitin ligase. J Virol 2005;79:3737-47.

26. Shim C, Zhang W, Rhee CH, Lee JH. Profiling of differentially expressed genes in human primary cervical cancer by complementary DNA expression array. Clin Cancer Res 1998;4:3045-50.

27. Wong YF, Selvanayagam ZE, Wei N, Porter J, et al. Expression genomics of cervical cancer: molecular classification and prediction of radiotherapy response by DNA microarray. Clin Cancer Res 2003;9:5486-92.

28. Sopov I, Sorensen T, Magbagbeolu M, Jansen L, et al. Detection of cancer-related gene expression profiles in severe cervical neoplasia. Int J Cancer 2004;112:33-43.

29. Cheng Q, Lau WM, Tay SK, Chew SH, et al. Identification and characterization of genes involved in the carcinogenesis of human squamous cell cervical carcinoma. Int J Cancer 2002;98:419-26.

30. Wong YF, Cheung TH, Tsao GS, Lo KW, et al. Genome-wide gene expression profiling of cervical cancer in Hong Kong women by oligonucleotide microarray. Int J Cancer 2006; 118:2461-9.

31. Chen Y, Miller C, Mosher R, Zhao X, et al. Identification of cervical cancer markers by cDNA and tissue microarrays. Cancer Res 2003;63:1927-35.

32. Fujimoto T, Nishikawa A, Iwasaki M, Akutagawa N, et al. Gene expression profiling in two morphologically different uterine cervical carcinoma cell lines derived from a single donor using a human cancer cDNA array. Gynecol Oncol 2004;93:446-53.

33. Chao A, Wang TH, Lee YS, Hsueh S, et al. Molecular characterization of adenocarcinoma and squamous carcinoma of the uterine cervix using microarray analysis of gene expression. Int J Cancer 2006;119:91-98.

34. Rosty C, Scheffer M, Tsafrir D, Stransky S, et al. Identification of a proliferation gene cluster associated with HPV E6/E7 expression level and viral DNA load in invasive cervical carcinoma. Oncogene 2005;24:7094-104.

35. Santin AD, Zhan F, Bignotti E, Siegel ER, et al. Gene expression profiles of primary HPV16- and HPV18-infected early stage cervical cancers and normal cervical epithelium: identification of novel candidate molecular markers for cervical cancer diagnosis and therapy. Virology 2005;331:269-91.

36. Ahn WS, Bae SM, Lee JM, Namkoong SE, et al. Searching for pathogenic gene functions to cervical cancer. Gynecol Oncol 2004;93:41-48.

37. Vazquez-Ortiz G, Ciudad CJ, Pina P, Vazquez K, et al. Gene identification by cDNA arrays in HPV-positive cervical cancer. Arch Med Res 2005;36:448-58.

38. Hudelist G, Czerwenka K, Singer C, Pischinger K, et al. cDNA array analysis of cytobrush-collected normal and malignant cervical epithelial cells: a feasibility study. Cancer Genet Cytogenet 2005;158:35-42.

39. Steinau M, Lee DR, Rajeevan MS, Vernon SD, et al. Gene expression profile of cervical tissue compared to exfoliated cells: impact on biomarker discovery. BMC Genomics 2005;6:64.

40. Nieh S, Chen SF, Chu TY, Lai HG, et al. Is p16(INK4A) expression more useful than human papillomavirus test to determine the outcome of atypical squamous cells of undetermined significance-categorized Pap smear? A comparative analysis using abnormal cervical smears with follow-up biopsies. Gynecol Oncol 2005;97:35-40.

41. Mikheev AM, Mikheeva SA, Liu B, Cohen P, Zarbl H. A functional genomics approach for the identification of putative tumor suppressor genes: Dickkopf-1 as suppressor of HeLa cell transformation. Carcinogenesis 2004;25:47-59.