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Federación Mexicana de Ginecología y Obstetricia, A.C.

2007, Number 04

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Ginecol Obstet Mex 2007; 75 (04)

Change of pulsatile release and luteinizing hormone response to naloxone related to testicle damage

Villanueva DCA, Pineda VR, Echavarría SMG, Juárez BA

Language: Spanish
References: 26
Page: 200-204
PDF size: 138.35 Kb.


ABSTRACT

Objective: To compare the pulsatile release of LH, the tone of endogenous opioids and the mass of LH secreted after a naloxone infusion in healthy subjects and patients with normogonadotropic oligospermia (NO) in a model of progressive testicular damage.
Patients and methods: Pulsatile secretion of LH was analyzed in a period of 8 hours in a group of healthy subjects (group 3, n=5), in patients with NO and FSH/LH ratio ‹1.6 (group 1, n=5) and in patients with NO and FSH/LH ratio ›1.6 (group 2, n=5). The area under the curve of LH response after naloxone infusion was also calculated.
Results: Free serum testosterone concentration was lower (p‹0.01) and estradiol concentration higher in patients with NO than control subjects (1 vs 3: p=0.01; 2 vs 3: p=0.001). Frequency of pulses in group 1 was 3.33 ± 0.57/8 h, in group 2: 4 ± 1/8 h; and in group 3: 2.66 ± 0.57/8 h (2 vs 3 p‹ 0.01; 2 vs 1 p= 0.05). The area under the curve after naloxone infusion was 19,300.44 ± 11,403.31 in group 1, 5,696.09 ± 1,753.44 in group 2; and 3,080.97 ± 1,159.78 in group 3 (1 vs 3 Anova p = 0.01).
Conclusions: The data indicate that patients with NO have a subclinical pantesticular failure and that the opioid tone is increased at the initial phase of testicular dysfunction, but it decreases at more advanced stages of testicular damage.


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