Esperanza S

Language: Spanish
References: 8
Page: 7-9
PDF size: 118.48 Kb.

ABSTRACT

The degenerative pathology of the lumbar spine represents a sanitary problem in Western countries. The acute lumbar pain is usually recurrent and in some patients who have a case history, this disease evolves to chronic pathologies. La WHO (World Health Organization) has recognized chronic pain as a disease per se. Up to the present, such clinical entity, presenting a high incidence all over the world, and with high costs for the medical systems and a large economic and social impact (labor absenteeism, early retirement, disability, among others), has not found the solution for its set of problems through the conventional treatments. During the last fifty years, several treatments have been studied in order to solve this world calamity. The result has been not only the development of scientific research but also the universal recognition of Pain Treatment as an Elementary Human Right. This should establish an imperative achievement of our days. The scientific community is placed in front of a big challenge when trying to continue with the development of ozone therapy in the treatment of pain.

REFERENCES

1. Protective effect of ozone treatment on the injury associated with hepatic ischemia-reperfusion: antioxidant-prooxidant balance. Free Radical Research 1999; 31: 191-196.

2. Effect of ozone treatment on reactive oxygen species and adenosine production during hepatic ischemia-reperfusion. Free Rad Res 2000; 33: 595-605.

3. Herniated lumbar intervertebral discs spontaneously produce matrix metalloproteinases, nitric oxide, interleukin-6, and prostaglandin E2. [Spine. 1996].

4. Toward a biochemical understanding of human intervertebral disc degeneration and herniation. Contributions of nitric oxide, interleukins, prostaglandin E2, and matrix metalloproteinases. [Spine. 1999].

5. The aging spine: the role of inflammatory mediators in intervertebral disc degeneration. [Cell Mol Biol (Noisy-le-grand). 2007].

6. Expression and distribution of tumor necrosis factor alpha in human lumbar intervertebral discs: a study in surgical specimen and autopsy controls. [Spine. 2005].

7. Ameliorative effect of ozone on cytokine production in mice injected with human rheumatoid arthritis synovial fibroblast cells. Rheumatol Int 2005; 26: 142-151.

8. Pharmacological mechanisms underlying oxygen-ozone therapy for herniated disc. Rivista Italiana di Ossigeno-Ozonoterapia 2003; 2: 7-11.