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2005, Number 2

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Bioquimia 2005; 30 (2)

Emergence resistance to carbapenems by metallo-β-lactamase-producing Pseudomonas aeruginosa

Andrade V

Language: Spanish
References: 51
Page: 53-58
PDF size: 75.12 Kb.


ABSTRACT

Carbapenems are commonly active anti-microbial agents used against multiresistant bacterial agents. However, carbapenem resistance has been described in many regions of the world as an emergent global issue. Pseudomonas aeruginosa is one of the etiologic agents causing nosocomial infections and capable to express mechanisms that generate resistance to different anti-microbial agents, including carbapenems. The primary carbapenem-resistance mechanism in Gram-negative bacillus is the production of Β-type lactamases, also called metallo-β-lactamases (M-βLs), that require zinc ions for enzyme activity. It has been reported that the distribution of M-βLS and the substrate profile they hydrolyze are different in each region of the world, considering that the evolutive divergence of these enzymes is a reflection of the clinical practice management of the various anti-microbial outlines and/or the dissemination of multi-resistant endemic clones. To this date, four families of M-βLs have been described: IMP, VIM, SPM and GIM, which have caused different variables with distinct catalytic features, making the therapy choice even more difficult. In this review, we will describe the M-βLs causing carbapenem-resistance and the expression of other extended-spectrum β-lactamase families that may contribute to the resistance of these anti-microbial agents.


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