medigraphic.com

2005, Number 2

<< Back Next >>

Bioquimia 2005; 30 (2)

Association among uric acid and calcium oxalate crystalluria with uricosuria, calciuria, and urinary pH

Medina-Escobedo M, Villanueva-Jorge S, González-Hoil D, Medina-Escobedo C

Language: Spanish
References: 21
Page: 47-52
PDF size: 63.64 Kb.


ABSTRACT

Analysis of crystals in the urinary sediment as well as calciuria and uricosuria can be usefulness in patients with urinary lithiasis, nevertheless, the degree of association is unknown among the number of calcium oxalate (CaOxC) and uric acid crystals (UAC) with the urinary pH (UpH), calciuria (CaU) and uricosuria (UU). The aim of this study was to establish a possible association between these. Fresh urine samples were analyzed: CaOxC and UAC were counted in a Kova chamber corroborating the composition with 10% NaOH and 10 % HCl; in addition we determined UpH, CaU and UU. There were included 372 samples, 140 of group I (healthy) and 232 of group II (with various clinical situation); 196 (52.7%) were men and 176 (47.3%) women; 30% had CaOxC and 5.3% UAC 2.6% had both types of crystals; there was difference between the averages of calciuria, uricosuria and pH (p ‹ 0.05), nevertheless there was no difference between the number of crystals when comparing both groups. Correlation Spearman test between CaOxC and UAC showed ra = 0.56 (p ‹ 0.001); the relation between CaOxC and UpH it was 1%; there was no association between UAC with UU and UpH. In conclusion, one third of the CaOxC are explained by the UAC and its relation with UpH is low, UAC does not show association with UU and UpH.


REFERENCES

  1. Bradley M, Schumann B. Estudio de la orina. En: Bernard J, Threatte G. (eds). Diagnóstico y tratamiento clínicos por laboratorio. 4ª ed. España: Salvat Editores; 1992: 471-568.

  2. Argeri N. El análisis de rutina de la orina. Fundamentos, interpretación de técnicas de las principales pruebas de laboratorio. En: Fishbach F (ed). Manual de pruebas diagnósticas. 5ª ed. México: Mc Graw-Hill; 1997: 25-80.

  3. Iovine E, Selva A. Orina y pruebas funcionales renales. En: Iovine E, Selva A. (eds) El laboratorio en la clínica. 2ª ed. Argentina: Panamericana; 1975: 249-313.

  4. Graff LS. Análisis de orina. Argentina: Panamericana; 1983: 70-90.

  5. Peña JC. Litiasis urinaria. En: Peña JC (ed). Nefrología clínica. México: Méndez Oteo; 1985: 393-420.

  6. Robles J, Armas C. Various epidemiological aspects of hyperuricemia and gout in Mexico: incidence and the cardiovascular risk factor. Arch Inst Cardiol Mex 1978; 48: 1121-41.

  7. Low RK, Stoller ML. Uric acid-related nephrolithiasis. Urol Clin North Am 1997; 24: 135-48.

  8. Curhan GC, Willet WC, Rimm EB, Speizer FE, Stampfer MJ. Body size and risk of kidney stones. J Am Soc Nephrol 1998; 9: 1645-1654.

  9. Argeri N. Los cálculos urinarios. En: Fishbach F (ed). Manual de pruebas diagnósticas. 5a ed. México: Mc Graw-Hill; 1997: 133-140.

  10. Nelson J, Moxness K, Jensen M, Gastineau C (eds). Dietética y nutrición. Manual de la clínica Mayo. 7° ed. México: Harcourt Brace; 1996: 331-357.

  11. Fogazzi GB. Crystalluria: a neglected aspect of urinary sediment analysis. Nephrol Dial Transplant 1996; 11: 379-387.

  12. Hulley S, Cummings S: Diseño de la investigación clínica. España: Doyma; 1993: 234.

  13. Daudon M, Jungers P, Lancour B. Clinical value of crystalluria study. Ann Biol Clin 2004; 62: 379-393.

  14. Coe FL, Strauss AL, Tembe V, Le Dun S. Uric acid saturation in calcium nephrolithiasis. Kidney Int 1980; 17: 662-668.

  15. Kaid-Omar Z, Daudon M, Attar A, Semmoud A, Lacour B, Addou A. Correlations between crystalluria and composition of calculi. Prog Urol 1999; 9: 633-641.

  16. Moesch C, Charmes JP, Bouthier F, Leroux-Robert C. Calcium oxalate crystalluria in elderly patients and treatment with naftidrofuryl oxalate. Age Ageing 1995; 24: 464-467.

  17. Medina-Escobedo M, Villanueva-Jorge S, Sánchez-Valladares R, Borges-Rivero M, Pardío-Marín JR, Tello J, et al. Examen general de orina en recién nacidos sanos. Bioquimia 2001; 26: 90-94.

  18. Medina-Escobedo M, Zaidi M, Real-de León E, Orozco-Rivadeneyra S. Prevalencia y factores de riesgo en Yucatán, México, para litiasis urinaria. Salud Pública Mex 2002; 44: 541-545.

  19. Medina-Escobedo M, Villanueva-Jorge S, Cisneros-Martínez E, Medina-Escobedo C, Gala-Trujano E. Cristaluria por ácido úrico en recién nacidos, su relación con la uricosuria y el pH. Bol Med Hosp Infant Mex 2003; 60: 591-596.

  20. Batinik D, Milosevic D, Blau N, Konjevoda P, Stambuk N, Barbarie V, et al. Value of the urinary stone promoters/inhibitors ratios in estimation of risk of urolithiasis. J Ches Inf Comput Sci 2000; 40: 607-610.

  21. Medina-Escobedo M, Medina-Escobedo C, Martín-Soberanis G. Frecuencia de las enfermedades del sistema urinario en niños atendidos en un Hospital General en Yucatán, México. Bol Med Hosp Infant Mex 2004; 61: 482-488.




2020     |     www.medigraphic.com