medigraphic.com
Anales de la Sociedad Mexicana de Oftalmología y Archivos de la Asociación Para Evitar la Ceguera en México

2008, Number 5

<< Back Next >>

Rev Mex Oftalmol 2008; 82 (5)

Actualidades en el tratamiento de la retinosis pigmentaria

Achar V, Zenteno JC

Language: Spanish
References: 35
Page: 309-313
PDF size: 29.49 Kb.


ABSTRACT

Retinitis pigmentosa is the most common inherited retinal dystrophy. The disease is a common cause of irreversible blindness and no definitive treatment is available to date. In the recent past years, a number of therapeutic modalities aimed to slow the degenerative process of the retina have been developed. In several of these therapies, results are promising. In this article, the results reached using vitaminotherapy, retinal tissue transplant, retinal prostheses, gene therapy, and hyperbaric therapy, among others, are revised.


REFERENCES

  1. Hims MM, Inglehearn CF. Retinitis pigmentosa: genes, proteins and prospects. Dev Ophthalmol 2003; 37:109-125.

  2. Stephen P. Daige, P, Lori S. Perspective on Genes and Mutations Causing Retinitis Pigmentosa. Arch Ophthalmol 2007; 125 (2):151-158.

  3. Berson EL, Sandberg MA, Hayes KC, Nicholson BWy cols. A randomized trial of vitamin A and vitamin E supplementation for retinitis pigmentosa. Arch Ophthalmol 1193; 111(6):761-772.

  4. Berson EL, Sandberg MA, Hayes KC, Nicholson BW y cols. Vitamin A supplementation for retinitis pigmentosa. Arch Ophthalmol 1993; 111(11):1456-1459.

  5. Berson EL. Treatment of Retinitis Pigmentosa with vitamin A. Digital J Ophthalmology 1998; 04(7) Disponible en www.djo.harvard.edu.

  6. Berson EL, Rosner B, Sandberg MA, Weigel-DiFranco C y cols. Clinical trial of docosahexaenoic acid in patients with retinitis pigmentosa receiving vitamin A treatment. Arch Ophthalmol 2004; 122(9):1297-1305.

  7. Berson EL, Rosner B, Sandberg MA, Weigel-DiFranco C y cols. Further evaluation of docosahexaenoic acid in patients with retinitis pigmentosa receiving vitamin A treatment: subgroup analyses. Arch Ophthalmol 2004;122(9):1306-1314.

  8. Hartong DT, Berson EL, Dryja TP. Retinitis pigmentosa. Lancet 2006; 368 (9549):1795-1809.

  9. Yu TY, Acosta ML, Ready S, Cheong YL, Kalloniatis M. Light exposure causes functional changes in the retina: increased photoreceptor cation channel permeability, photoreceptor apoptosis, and altered retinal metabolic function. J Neurochem 2007; 103(2):714-724.

  10. Paskowitz DM, Duncan JL. Light and inherited retinal degeneration. Br J Ophthalmol 2006; 90(8):1060-6.

  11. Wang M, Tso MOM, Naash MI. Expression of a mutant opsin gene increases the susceptibility of the retina to light damage. Vis Neuroscience 1997; 1455-62.

  12. Hamel C. Retinitis pigmentosa. Orphanet J Rare Diseases 2006; 1(40).

  13. Berson EL. Light deprivation and retinitis pigmentosa. Vision Res 1980; 20 (12):1179-1184.

  14. Miyake Y, Horiguchi M, Yagasaki K. Light deprivation and retinitis pigmentosa Am J Ophthalmol 1990; 110(3):305-306.

  15. Vingolo EM, Pelaia P, Forte R, Rocco M, Giusti C, Rispoli E. Does hyperbaric oxygen (HBO) delivery rescue retinal photoreceptors in retinitis pigmentosa? Doc Ophthalmol 1999; 97(1):33-39.

  16. Stone J, Maslim J, Valter K, Hollander H. The influence of oxygen levels on the death and survival of photoreceptors. Retinal Degeneration in Degenerative Diseases of the retina 1996: 371–377.

  17. Vingolo EM, Rocco M, Grenga PG, Salvatore S, Pelaia P. Slowing the degenerative process, long lasting effect of hyperbaric oxygen therapy in retinitis pigmentosa. Graefes Arch Clin Exp Ophthalmol 2007; 246:93–98

  18. Otani A, Dorrel MI, Kinder K, Moreno SK, Nusinowitz S, Banin E. Rescue of retinal degeneration by intravitreally injected adult bone marrow derived lineage-negative hematopoietic stem cells. J Clin Invest 2004; 114(6):765-774.

  19. Kociok N. Can the injection of the patient’s own bone marrow-derived stem cells preserve cone vision in retinitis pigmentosa and other diseases of the eye? Graefes Arch Clin Exp Ophthalmol 2005; 243(3):187-188.

  20. Mezey E, Chandross KJ, Harta G, Maki RA, McKercher SR. Turning blood into brain: cells bearing neuronal antigens generated in vivo from bone marrow. Science 2000; 290 (5497):1779-1782.

  21. Zrenner E, Besch D, Bartz-Schmidt KU, Gekeler F y cols. Subretinal chronic multi-electrode arrays implanted in blind patients. Invest Ophthalmol Vis Sci 2006; 47:1538.

  22. Yanai DWJ, Mahadevappa M, Greenberg RJ, Fine I, Humayun MS. Visual performance using a retinal prosthesis in three subjects with retinitis pigmentosa. Am J Ophthalmol 2007; 143(5):820-827.

  23. Acland GM, Agirre GD, Ray J, Zhang Q, Aleman TS y cols. Gene therapy restores vision in a canine model of childhood blindness. Nat Genet 2001; 28:92-95.

  24. Acland GM, Aguirre GD., Bennett J, Aleman TS y cols. Longterm restoration of rod and cone vision by single dose rAAVmediated gene transfer to the retina in a canine model of childhood blindness. Mol Ther 2005; 12:1072-1082.

  25. Weber M, Provost N, Conrath H, Folliot S, Briot D y cols. Recombinant adeno-associated virus serotype 4 mediates unique and exclusive long-term transduction of retinal pigmented epithelium in rat, dog, and nonhuman primate after subretinal delivery. Mol Ther 2003; 7:774-778.

  26. Min SH, Molday LL, Seeliger MW, Dinculescu A y cols. Prolonged recovery of retinal structure/function after gene therapy in an Rs1h-deficient mouse model of x-linked juvenile retinoschisis. Mol Ther 2005; 12:644-651.

  27. Kairisalo M, Korhonen L, Blomgren K, Lindholm D. X-linked inhibitor of apoptosis protein increases mitochondrial antioxidants through NF-kappaB activation. Biochem Biophys Res Commun 2007; 364(1):138-144.

  28. Leonard KC, Petrin D, Coupland SG, Baker AN y cols. XIAP protection of photoreceptors in animal models of retinitis pigmentosa. PLoS ONE 2007; 2(3): 314.

  29. Bainbridge JW, Smith AJ., Barker SS, Robbie S y cols. Effect of gene therapy on visual function in Leber’s congenital amaurosis. N Engl J Med 2008; 358(21): 2282-2284.

  30. Radtke ND, Aramant RV, Seiler MJ, Petry HM, Pidwell D. Vision change after sheet transplant of fetal retina with retinal pigment epithelium to a patient with retinitis pigmentosa. Arch Ophthalmol 2004; 122(8):1159-1165.

  31. Ghosh F, Engelsberg K., English RV, Petters RM. Long-term neuroretinal full-thickness transplants in a large animal model of severe retinitis pigmentosa. Graefes Arch Clin Exp Ophthalmol 2007; 245(6):835-846.

  32. Radtke ND, Aramant RV, Petry HM, Green PT, Pidwell DJ, Seiler MJ. Vision Improvement in Retinal Degeneration Patients by Implantation of Retina Together with Retinal Pigment Epithelium. Am J Ophthalmol 2008; en prensa.

  33. Samardzija M, Wenzel A., Thiersch M, Frigg R, Remé C, Grimm C. Caspase-1 ablation protects photoreceptors in a model of autosomal dominant retinitis pigmentosa. Invest Ophthalmol Vis Sci 2006; 47(12):5181-5190.

  34. Sahel JA. Saving cone cells in hereditary rod diseases: a possible role for rod-derived cone viability factor (RdCVF) therapy. Retina 2005; 25(8 Supl):S38-S39.

  35. Boatright JH, Moring AG, McElroy C, Phillips MJ, Do VT y cols. Tool from ancient pharmacopoeia prevents vision loss. Mol Vis 2006; 12:1706-1714.




2020     |     www.medigraphic.com