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Anales de la Sociedad Mexicana de Oftalmología y Archivos de la Asociación Para Evitar la Ceguera en México

2008, Number 2

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Rev Mex Oftalmol 2008; 82 (2)

Estudio de la seguridad y eficacia del hialuronato de sodio y sulfato de condroitín versus carboximetilcelulosa en el síndrome de ojo seco

Baiza DLM, Álvarez DJ, Contreras RY, Medrano PJ, Quintana HJD, Alaníz OJF, Anaya GME, Cantero VMA, Gómez-Bastar P, Hernández QE

Language: Spanish
References: 19
Page: 86-90
PDF size: 89.06 Kb.


ABSTRACT

Purpose: To evaluate the safety and efficacy of a sodium hyaluronate and chondroitin sulfate ophthalmic solution in comparison to a carboxymethyl cellulose solution for the treatment of dry eye syndrome.
Materials and methods: This was a prospective, randomized and double-blind clinical study. 102 patients diagnosed with mild to moderate dry eye syndrome were included. For each patient, a sodium hyaluronate/chondroitin sulfate fixed combination solution or a carboxymethyl cellulose was randomly applied on the ocular surface four times a day during 60 days. The safety, efficacy and tolerance parameters were evaluated on days 2, 7, 15, 30 y 60.
Results: There was no statistically significant difference between the two treatment groups in terms of burning sensation, tearing, foreign body sensation and fluorescein staining. However, there is a favorable tendency for hyaluronate sodium sulfate and chondroitin in most of the parameters evaluated.
Conclusions: The topical application of hyaluronate sodium sulfate and chondroitin is as safe as carboxymethyl-cellulose drops in patients with mild to moderate dry eye syndrome. There is a significant tendency in favor of hyaluronate sodium sulfate and chondroitin in most of the evaluated clinical parameters.


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