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2004, Number 3

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Bioquimia 2004; 29 (3)

Proposal of a construct for the integral measurement of oxidative stress

Sánchez-Rodríguez MA, Santiago-Osorio E, Vargas LA, Mendoza-Núñez VM

Language: Spanish
References: 70
Page: 81-90
PDF size: 127.65 Kb.


ABSTRACT

Oxidative stress (OxS) is a serious imbalance between the overproduction of free radicals (FR) and the effective action of the antioxidant system that produce oxidative damage to the biomolecules. This OxS has been associated with the aging process and more than a hundred different diseases. However, there is not an operative definition that includes all biomarkers implied in this process integrally, giving as result confusion and theoretical misinterpretations. The objective of this paper is to theoretically fundament the proposal of an integral and dynamic construct that considers the concentration of oxidized biomolecules and the components of the antioxidant (intracellular and extracellular) systems. In this construct we propose the integral measurement of OxS through the evaluation of the efficiency the antioxidant system, and the establishment of categories for: a) the efficient antioxidant system (EAS) when it neutralize the harmful action of FR; b) antioxidant enzymatic deficiency (AEDN) if it generates OxS due to inefficient or insufficient action of antioxidant enzymes; c) antioxidant exogenous deficiency (AEXD) when the antioxidant biomolecules from exogenous source are not capable to neutralize FR; and d) antioxidant system global deficiency (ASGD) if the antioxidant endogenous and exogenous molecules show an unbalance in favor of FR. This is an alternative proposal for the evaluation and interpretation of OxS in an integral fashion.


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