Monteagudo-Sánchez B, Peteiro A, Fachal C, Allegue F, Ortiz-Rey JA

Language: Spanish
References: 16
Page: 208-210
PDF size: 188.34 Kb.

ABSTRACT

The Muir-Torre syndrome is an autosomal dominant inherited genodermatosis associating multiple low-grade visceral tumors, namely colorectal carcinomas, with sebaceous tumors of the skin. It is a phenotypic subset of hereditary nonpolyposis colorectal cancer. The defect is thought tobe the result of a mutation in mismatch repair genes and associated with microsatelite instability. We report two cases of Muir-Torre syndrome and show immunohistochemical analysis of the sebaceous neoplasm.

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