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ISSN 0210-5187 (Electronic)

2008, Number 3

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Med Cutan Iber Lat Am 2008; 36 (3)

Immune reconstitution inflammatory syndrome (IRIS). A review to understand

Fernández-Martínez RF, Arenas R

Language: Spanish
References: 26
Page: 113-119
PDF size: 157.75 Kb.


ABSTRACT

The immune reconstitution inflammatory syndrome is commonly seen in patients with HIV/AIDS after weeks to months of antiretroviral therapy (ART), this condition may be severe. They occur when were treated previously for an opportunistic infection, which we considered successfully cured, or when a latent opportunistic infection becomes apparent and finally when an opportunistic infection under treatment exacerbates. Incidence is 10 to 25% in patients of all ages which start with ART, and 45% in those with an opportunistic infection. It is seen more frequently when counts of CD4+ are ‹ 50 cels/mm3 and as a result of the recovery of the immune response.
The immunopathogenesis is unknown, but it is supposed to be triggered by antigens and infective organisms. This syndrome lasts for weeks to months; most of the cases are mild and resolve spontaneously. The cutaneous manifestations are present in 50%. The treatment consists on continuing the ART and to start, continue or adjust the treatment of the opportunistic infection, and the use of corticosteroids or non steroid anti-inflammatory agents if needed.


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