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Órgano Oficial del Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz

2003, Number 1

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Salud Mental 2003; 26 (1)

Participación del cerebelo y del hipocampo en el condicionamiento clásico del reflejo corneal

Delgado-García JM

Language: Spanish
References: 30
Page: 1-10
PDF size: 554.83 Kb.


ABSTRACT

The classical conditioning of nictitating membrane/eyelid responses is one of the most frequently used experimental models for the study of learning and memory mechanisms in mammals. Our research group has carried out a detailed study of the kinetic properties of reflex, voluntary and emotional eyelid responses, as well as those characterizing classically conditioned blink responses. On the other hand, we have studied the location and, in particular, the firing properties of facial motoneurons innervating the orbicularis oculi muscle during the performance of those types of eyelid reflex and learned responses. Facial motoneurons encode the speed of eyelid displacement during reflexively evoked blinks, but they encode eyelid position during the performance of learned blink responses. This noticeable difference suggests a different processing and/or neural origin of both types of motor command. The paravermal cortex and the rostral pole of the posterior interpositus nucleus are apparently involved in reflex and learned eyelid responses, contributing to their correct performance, but not to the acquisition of new motor abilities carried out with the lid. Another cerebral structure involved in classical conditioning of eyelid responses is the hippocampus, contributing to determine the relevance or predictive value of the conditioning stimulus, during classical conditioning paradigms. Finally, an integrated view of the premotor facial system and of the future lines of research in this experimental model of associative learning in mammals is also presented


REFERENCES

  1. AOU S, WOODY CD, BIRT D: Changes in the activity of units of the cat motor cortex with rapid conditioning and extinction of a compound eye blink movement. J Neurosci, 12:549-559, 1992.

  2. BECKER W, FUCHS AF: Lid-eye coordination during vertical gaze changes in man and monkey. J Neurophysiol, 60:1227- 1252, 1988.

  3. BLISS TVP, COLLINGRIDGE GL: A synaptic model of memory: long-term potentiation in the hippocampus. Nature, 361:31-39, 1993.

  4. BRACHA V, BLOEDEL JR: The multiple-pathway model of circuits subserving the classical conditioning of withdrawal reflexes. En: Bloedel JR , Ebner TJ , Wise SP (eds.) The Acquisition of Motor Behavior in Vertebrates. The MIT Press, 175-204, Cambridge, 1996.

  5. CLARK RE, SQUIRE LR: Classical conditioning and brain systems: The role of awareness. Science, 280:77-81, 1998.

  6. DELGADO-GARCIA JM, EVINGER C, ESCUDERO M, BAKER R: Behavior of accessory abducens and abducens motoneurons during eye retraction and rotation in the alert cat. J Neurophysiol, 64:413-422, 1990.

  7. DELGADO-GARCIA JM, GRUART E: The role of interpositus nucleus in eyelid conditioned responses. Cerebellum, 1:289-308, 2002.

  8. EDWARDS FA: LTP  a structural model to explain the inconsistencies. TINS, 18:250-255, 1995.

  9. EVINGER C, MANNING KA, SIBONY PA: Eyelid movements. Mechanisms and normal data. Invest Ophthalmol Visual Sci, 32:387-400, 1991.

  10. GORDON G: Observations upon the movement of the eyelids. Br J Ophthalmol, 35:339-351, 1951.

  11. GORMEZANO I, KEHOE EJ, MARSHALL BS: Twenty years of classical conditioning research with the rabbit. Prog Psychobiol Physiol Psychol, 10:197-275, 1983.

  12. GORMEZANO I, SCHNEIDERMAN N, DEAUX E, FUENTES I: Nictitating membrane: classical conditioning and extinction in the albino rabbit. Science, 138:33-34, 1962.

  13. GRUART A, BLAZQUEZ P, DELGADO-GARCIA JM: Kinematics of spontaneous, reflex, and conditioned eyelid movements in the alert cat. J Neurophysiol, 74:226-248, 1995.

  14. GRUART A, BLAZQUEZ P, PASTOR AM, DELGADOGARCIA JM: Very short term potentiation of climbing fiber effects on deep cerebellar nuclei neurons by conditioning stimulation of mossy fiber afferents. Exp Brain Res, 101:173- 177, 1994.

  15. GRUART A, DELGADO-GARCIA JM: Discharge of identified deep cerebellar nuclei neuronsrelated to eye blinks in the alert cat. Neuroscience, 61:665-681, 1994.

  16. GRUART A, GUILLAZO-BLANCH G, FERNANDEZMAS R, JIMENEZ-DIAZ L, DELGADO-GARCIA JM: Cerebellar posterior interpositus nucleus as an enhancer of classically conditioned eyelid responses in alert cats. J Neurophysiol, 84:2680-2690, 2000.

  17. GRUART A, MORCUENDE S, MARTINEZ S, DELGADO- GARCIA JM: Involvement of cerebral cortical structures in the classical conditioning of eyelid responses in rabbits. Neuroscience, 100:719-730, 2000.

  18. GRUART A, PASTOR AM, ARMENGOL JA, DELGADOGARCIA JM: Involvement of cerebellar cortex and nuclei in the genesis and control of unconditioned and conditioned eyelid motor responses. Prog Brain Res, 114:511-528, 1997.

  19. GRUART A, SCHREURS BG, DOMINGUEZ DEL TORO E, DELGADO-GARCIA JM: Kinetic and frequency-domain properties of reflex and conditioned eyelid responses in the rabbit. J Neurophysiol, 83:836-852, 2000.

  20. HAWKINS RD, ABRAMS TW, CAREW TJ, KANDEL ER: A cellular mechanism of classical conditioning in Aplysia: activity-dependent amplification of presynaptic facilitation. Science, 219:400-405, 1983.

  21. ITO M: Long-term depression. Annu Rev Neurosci, 12:85- 102, 1989.

  22. MAGARIÑOS-ASCONE C, NUÑEZ A, DELGADOGARCIA JM: Different discharge properties of rat facial nucleus motoneurons. Neuroscience, 94:879-886, 1999.

  23. MALENKA RC: LTP and LTD: dynamic and interactive processes of synaptic plasticity. Neuroscientist, 1:35-42, 1995.

  24. MORCUENDE S, DELGADO-GARCIA JM, UGOLINI G: Neuronal premotor networks involved in eyelid responses: retrograde transneuronal tracing with rabies virus from the orbicularis oculi muscle in the rat. J Neurosci, 22:8808-8818, 2002.

  25. MUNERA A, GRUART A, MUÑOZ MD, FERNANDEZMAS R, DELGADO-GARCIA JM: Hippocampal pyramidal cell activity encodes conditioned stimulus predictive value during classical conditioning in alert cats. J Neurophysiol, 86:2571-2582, 2001.

  26. RESCORLA RA: Behavioral studies of pavlovian conditioning. Annu Rev Neurosci, 11:329-352, 1988.

  27. THOMPSON RF, KRUPA DJ: Organization of memory traces in the mammalian brain. Annu Rev Neurosci, 17:519-549, 1994.

  28. TRIGO J A, GRUART A, DELGADO-GARCÍA J M: Discharge profiles of abducens, accessory abducens, and orbicularis oculi motoneurons during reflex and conditioned blinks in alert cats. J Neurophysiol, 81:1666-1684, 1999.

  29. TRIGO JA, GRUART A, DELGADO-GARCIA JM: Role of proprioception in the control of lid position during reflex and conditioned blink responses in the alert behaving cat. Neuroscience, 90:1515-1528, 1999.

  30. WOODY CD: Understanding the cellular basis of memory and learning. Annu Rev Psychol, 37:433-493, 1986.




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