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Instituto Nacional de Salud Pública

2002, Number 3

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salud publica mex 2002; 44 (3)

Association between cardiovascular disease and antibodies against Chlamydia pneumoniae.

García-Elorriaga GGA, Calderón-Abbo MM, González-Bonilla CCR

Language: Spanish
References: 26
Page: 243-246
PDF size: 40.45 Kb.


ABSTRACT

Objective. To evaluate the association between cardiovascular disease (CVD) and antibodies against Chlamydia in Mexican population. Material and Methods. A cross-sectional study was conducted from August 1988 to April 2000, at the Immunology and Infectology Research Unit of Hospital de Infectología, Centro Médico Nacional La Raza (CMNR)– and at the Cardiovascular Surgery and Circulatory Care, Hospital General CMNR, Instituto Mexicano del Seguro Social (IMSS). Study subjects were 70 CVD hospitalized patients, older than 30 years, from both genders. Serum IgG and IgM antibodies against C. psitaccii, C. trachomatis and C. pneumoniae were determined by microimmunofluorescence in study subjects and compared with those from 140 healthy individuals, matched by age and sex. Simple random sampling was used, for an expected prevalence of 50% and a 99% confidence level; the sample size was 110 subjects. The chi-squared test and odds ratios were used to compare proportions. Results. IgG antibodies against C. pneumoniae were found in 94.3% (66/70) patients, as compared to only 37% (52/140) of healthy individuals (p‹0.001). Conclusions. An association between IgG antibodies against C. pneumoniae and CVD was found. This finding warrants further studies to evaluate the role of C. pneumoniae as a predictor of CVD.


REFERENCES

  1. Saikku P, Leinonen M, Mattila K, Nieminen MS, Makela PH, Huttunen JK et al. Serological evidence of an association of a novel Chlamydia TWAR, with chronic coronary heart disease and acute myocardial infection. Lancet 1988; 2:983-986.

  2. Danesh J, Collins R, Peto R. Chronic infections and coronary heart disease is there a link? Lancet 1997 350:430-436.

  3. Fagerberg B, Gnarpe J, Gnarpe H. C. pneumoniae but not cytomegalovirus antibodies are asscociated with future risk of stroke and cardiovascular disease. Stroke 1999; 30:299-305.

  4. Tiran A, Tio RA, Ossewaarde JM, Tiran B, Den Heijer P, The TH et al. Coronary angioplasty induces rise in C. pneumoniae-specific antibodies. J Clin Microbiol 1999; 37(4):1013-1017.

  5. Sessa R, Di Pietro M, Santino I, Del Piano M, Varveri A, Dagianti A et al. C. pneumoniae infection and atherosclerotic coronary disease. Am Heart J 1999; 137(6):1116-1119.

  6. Kontula K, Vuorio A, Turtola H, Saikku P. Association of seropositivity for C. pneumoniae and coronary artery disease in heterozygous familial hypercholesterolaemia (letter). Lancet 1999; 354(9172):46-47.

  7. Leowattana W, Mahanonda N, Bhuripunyo K, Leelarasamee A, Pokum S, Suwimol B. The prevalence of C. pneumoniae antibodies in Thai patients with coronary artery disease. J Med Assoc Thai. 1999; 82(8):792-797.

  8. Shimada K, Mokuno H, Watanabe Y, Sawano M, Sato H, Kurata T et al. Association between chlamydial infection and coronary artery disease. J Cardiol 1999; 34(5):259-265.

  9. Nobel M, De Torrente A, Peter O, Genne D. No serological evidence of association between Chlamydia pneumoniae infection and acute coronary heart disease. Scand J Infect Dis 1999; 31(3):261-264.

  10. Romeo F, Martuscelli E, Chirieolo G. Seropositivity against C. pneumoniae in patients with coronary atherosclerosis. Clin Cardiol 2000; 23(5):327-330.

  11. Ridker PM, Kundsin RB, Stmapfer MJ, Poulin S, Hennekens CH. Prospective study of C. pneumoniae IgG seropositivity and risks of future myocardial infarction. Circulation 1999; 99(9):1161-1164.

  12. Shor A, Kuo CC, Patton DL. Detection of C. pneumoniae in coronary arterial fatty streaks and atheromatous plaques. S Afr Med J 1992;82: 158-161.

  13. Ramírez JA, C. pneumoniae / Atherosclerosis Study Group. Isolation of C. pneumoniae from the coronary artery of a patient with coronary atherosclerosis. Ann Intern Med 1996; 125:979-982.

  14. Bachmaier K, Neu N, De la Maza L, Pal S, Hessel A, Penninger J. Chlamydia infections and heart disease linked through antigenic mimicry. Science 1999; 283:1335-1339.

  15. Meier CR. Antibiotics in the prevention and treatment of coronary heart disease. J Infect Dis 2000 181 (Suppl 3):S558-S562.

  16. Gurfinkel E. Inflammation, infection, or both in atherosclerosis: The ROXIS trial in perspective. J Infect Dis 2000; 181 (Suppl 3):S566-S568.

  17. Dunne MW. Rationale and design of a secondary prevention trial ofantibiotic use in patients after myocardial infarction: The WIZARD (weekly inervention with zithromax [azithromycin] for atherosclerosis and its related disorders) trial. J Infect Dis 2000; 181 (suppl 3):S572-S578.

  18. Gloria FB, Meaney EM, Valero GE. Investigación clínica. La relación entre C. pneumonaie y las lesiones aterosclerosas aórticas. Arch Inst Cardiol Mex. 1997; 67:17-23.

  19. Sánchez-González J, Moragrega-Adame JL, Rivera-Cisneros AE, Gil-Camarena F, Andrade-Quezada M. Seropositividad a C.pneumoniae y su asociación con enfermedad cardiovascular. Rev Mex Patol Clin 2000; 47(1):4-12.

  20. Grayston JT, Wang SP, Kuo CC. Current knowledge on C. pneumoniae, strain TWAR, an important cause of pneumonia and other acute respiratory diseases. Eur J Clin Microbiol Infect Dis 1989; 8:191-202.

  21. Patel P, Mendall MA, Carrington D, Strathan D, Leatham E, MolineauxN et al. Association of Helicobacter pylori and C. pneumoniae infections with coronary heart disease and cardiovascular risk factors. BMJ 1995; 311:711-714.

  22. Kuo CC, Shor A, Campbell LA. Demonstration of C. pneumoniae in atherosclerosis lesions of coronary arteries. Infect Dis 1993; 167: 841-849.

  23. Coles KA, Plant AJ, Riley TV, Smith DW, McQuillan BM, Thompson PL.Lack of association between seropositivity to C. pneumoniae and carotid atherosclerosis. Am J Cardiol 1999; 84(7):825-828.

  24. Paterson DL, Hall J, Rasmussen SJ. Failure to detect C. pneumoniae atehrosclerotic plaques of Australian patients. Pathology 1998;30:169-172.

  25. Weiss S, Roblin P, Gaydos C. Failure to detect C. pneumoniae in coronary atheromas of patients undergoing atherectomy. Infect Dis 1996;173:957-962.

  26. Carter MW, Aj-Mahdawi SA, Giles JG. Nucleotide sequence and taxonomic value of the mayor outer membrane protein gene of C. pneumoniae IOL-207. J Gen Microbiol 1991;137:465-475




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