Ortega-Santana JF, Santamaría-León S, Vázquez-Anaya H

Language: Spanish
References: 16
Page: 4-8
PDF size: 54.68 Kb.

ABSTRACT

Objective: To compare the results of the progression of glaucomatous visual field defects in patients with primary open-angle glaucoma that receive oral pentoxifilyne.
Materials and methods: A randomized clinical rehearsal was realized. Twenty patients were divided in two groups; group one received medical treatment with ocular hypotensive agents of first line, group two received medical treatment with ocular hypotensive agents of first line adding oral pentoxifilyne. Automated visual fields were realized in both groups: initial, 2 weeks, 1, 6 and 12 months, to compare the progression of the damage in the visual fields, between both groups, based on the mean deviation and the standard pattern deviation.
Results: In group one, there were a female predominance 70% with a mean age of 51 years, the progression of the mean deviation was –0.58 db and 0.46 db for the standard pattern deviation. In group two, 60% were females with a mean age of 61 years, the progression of the damage in the visual field was –0.05 db in the mean deviation and 0.187 db for the standard pattern deviation
Conclusions: Pentoxifiline, as auxiliary treatment, is able to reduce the progression of visual field defects in patients with open angle glaucoma.

REFERENCES

1. American Academy of Ophtalmology. Glaucoma. Curso de ciencias Básicas y Clínicas. Lifelong Education for the Ophthalmologist. Edición 1998-1999.

2. Yanoff, Mirón. Ophtalmology. London, Mosby, 1999.

3. Hamard PH, Duxaux J. Blood flow rate in the microvasculature of the optic nerve head in primary open angle glaucoma. A new approach Surv Ophtalmol 1994; 38: S87-93-94.

4. Trope GE, Salinas RG, Glynn M. Blood viscosity in primary open angle glaucoma Can J Opthalmol 1987; 22(4):202-4.

5. GE J, Zhou W, Ahu J, Cheng A, Lin Y, Tong H, Lian L, Chen Z. The study of relationships between the damage of visual function and hemorrheology, ocular rheography, as web as other related factor in patients with primary open angle glaucoma (POAG). Yan Ke Xue Bao 1993; (1):3-1.

6. Ates H, Uuretem O, Temiz A, Andac K. Erythrocyte deformability in high-tension and normal tension glaucoma. Int Ophtalmol 1998; 22(1):7-12.

7. Ritch R. The glaucomas. Basic Sciences. 2nd Ed. Mosby, 1986.

8. Tasman, Jager. Duane’s Clinical Ophtalmology. CD-ROM. Lippincott Williamn & Wilkins, 2003.

9. Rodríguez-Carranza R. Vademécum Académico de medicamentos. 3a ed México, McGraw-Hill Interamericana, 1999.

10. Jay WM, Asís MZ, Chapman JM, Green K. Effect of oral or intrevenous pentoxifilyne on ocular and optic nerve blood flow. Ophtalmic Res 1987; 19(6):318-21.

11. Schmetterer L, Kemmler D, Breiteneder H, Alschinger C y col. A randomized, placebo-controlled, double blind crossever study of the effect of the pentoxifilyne on ocular fundus pulsations. Am J Opthalmol 1996; 121(2):169-76.

12. Kruger A, Matulla B, Wolzt M, Pieh S, Strenn K y col. Shortterm oral pentoxifilyne use increase choroidal blood flow in patients with age-related macular degeneration. Arch Ophtalmol 1998; 116(1):27-30.

13. Flower RW, Lim Jl. An ICG angiogran-based clinical method for characterizing the choroidal circulation used to assess the hemorrheologic effects of pentoxifilyne, J Fr Ophtalmol 2000; 23(8):756-62.

14. Wallace L.M. Glaucoma. Los requisitos en oftalmología. Harcourt Mosby, 2001.

15. Hodapp E, Parrish RK Anderson DR. The asymptomatic patient with elevated pressure. Clinical Decisions in Glaucoma. St. Louis, CV Mosby, 1993:53.

16. AGIS Investigators. The glaucoma Intervention Study (AGIS):7. Relationships Between Control of Intraocular Pressure and Visual Field Deterioration. Am J Ophthalmol 2000; 130(4):429-440.