2002, Number 1
<< Back Next >>
Rev Mex Anest 2002; 25 (1)
Anestesia peridural con ropivacaína vs bupivacaína para la cirugía abdominal en pacientes ginecológicas.
Torres GV, Torres HM
Language: Spanish
References: 24
Page: 29-33
PDF size: 297.04 Kb.
ABSTRACT
Background: To define if epidural ropivacaine is more effective than epidural bupivacaine used in patients undergoing abdominal gynecological surgery.
Material and Methods: Thirty ASA II scale female patients with age range 30 to 60 years scheduled for gynecological surgery were included in this clinical trial. Group I (n=15) received ropivacaine 0.75%, for a dose of 116-150 mg (15-25 ml); Group II (n=15) received bupivacaine received bupivacaine 0.5% for a dose of 100-140 mg epidurally (L2-3). Heart rate (FC), systolic, diastolic and mean arterial pressure were recorded (PAS, PAD, PAM) every 5 minutes, as well as latency and analgesic length. The statistical analysis included mean, standard deviation, Student T test and chi square.
Results: Analgesic length: Group I was significantly longer than the second group (p‹0.001) with a mean of 204.6±20.1 minutes vs 162.4±29.1 minutes. PAS, PAD, FC and PAM showed significantly shorter variation in group I as compared with the second group (p‹0.001) from minutes 5, 10, 15 and 20 after the uses of the anesthetics.
Discussion: Ropivacaine is better local anesthetic than bupivacaine due to it’s tolerability and good level of analgesia/anesthesia.
REFERENCES
Scott BD, Lee A, Fagan D, Bowler GMR, Bloomfield P, Lundth R. Acute toxicity of ropivacaína compared with that of bupivacaine. Anesth. Analg. 1989; 69: 563-69.
Wolff AP, Hasselstróm, Kerkkamp HE, Gielen MJ. Extradural ropivacaína and bupivacaína in hip surgery. Br J Anaesth 1995; 74: 485-90.
Wahedi W, Nolte H, Ropivacaine for spinal anaesthesia. Abstract. Reg Anaesth 1993, 18 suppl, 62.
Van Kleef W, Nolte H, Spinal anaesthesia with ropivacaine a double blind study in patients undergoing minor lower limb surgery. Anesth Analg 1994, 78: 1125-30.
Concepción M, Arthur G, Steele S, Bader A, Covino B. A new local anesthesic, ropivacaine. Anesth Analg 1990, 70: 80-85.
Arthur GR, Feldman HS, Covino BG. Comparative pharmacokinetics of bupivacaine and ropivacaine a new amide local anesthesic. Anesth Analg 1988; 67: 1053-8.
Bader AM, Datta S, Flanagan H, Covino BG. Comparision of bupivacaína and ropivacaína induced conduction blockade in the isolated rabbit vagus nerve. Anesth Analg 1989; 68: 724-27.
Bannister C, Clark C, Littlewood DG. Ropivacaine a preliminary clinical trial. Br J Anaesth 1989; 63 2 237 abs.
Brockway MS, Baninister J, Mc Clure JH, Mckeown D, Wilsmith JAW. Comparision of extradural ropivacaine and bupivacaine. Br J Anaesth 1990, 64: 31-37.
Katz JA, Brudenbaugh PO, Knarr DC, Helton SH, Denson DD. Pharmacodynamics and Pharmacokinectics of peridural ropivacaine in humans. Anaesth Analg 1990, 70: 16-21.
Lee A; Fagan A, Lamont M, Tucker GT, Hallidin M, Scoth DB. Disposition kinetic of ropivacaine in humans. Anaesth Analg 1989, 69: 736-38.
Oda Y, Furuichi K, Tanaka K, Hiroi T, Imoka S, Asada A, Fujimori M, Funae Y. Metabolism of a new local anesthesic ropivacaine by human hepatic cytocrome p 450. Anesthesiology 1995, 82 1: 214-20.
Veering BT, Burn AGL. Pharmacokinectic and pharmacodynamics of medular agents. Bailleres clin. Anaesthesiology 1995, 82 1: 214-20.
Brown Dl, Carpenter RL. Thopson GE. Comparision of 0.55 ropivacaine and 0.55 bupivacaine for epidural anaesthesia in patients undergoing lower extremity. Surgery 1990, 72: 633-36.
Zaric D, Axelsson K, Phillipson L, Nydahy PA, Lasson P, Jasson JR, Leissner P. Sensory and motor blockade during epidural analgesia with 15, 0.755 and 0.55 ropivacaine a double-blind study. Anesth Analg 1991, 72: 509-15.
Emanuelson BMK, Zarick D, Nydahi PA, Axelsson KH. Phatmacokinetics of ropivacaine and bupivacaine during 21 hours continues epidural infusion in healthy male voluntaries. Anaesth Analg 1995, 81: 1163-8.
Etches R, Writer WD, Ansley D, Hydahy PA, Ong BY, Lui A, Banner N, Kawasaki S, Muir H, Beattle WS. Continues epidural ropivacaine 0.2% for analgesia after lower abdominal surgery. Anaesth Analg 1997, 84 (4): 784-90.
Scott DA, Chamley D, Mooney PH, Mark T, Deam RK. Epidural ropivacaine infusion for postoperative analgesia after major lower abdominal surgery a dose finding study. Anesth Analg 1995, (8): 982-86.
Feldmann HS, Arthur GR, Pitkanen M, Hurley R, Doucette AM, Covino BG. Treatmen of acute systemic toxicity after the rapid intravenous injection of ropivacaine and bupivacaine in the conscious dog. Anesth Analg 1991, 73 (4): 373-84.
Feldmann HS, Dvoskin S, Arthur RA, Doucette AM. Antinociceptive and motorblocking efficacy of ropivacaine and bupivacaine after epidural administration in the dog. Reg Anaesth 1996, 21: 318-26.
Wulf H, Petry A, Godicke. Die potentialangigkeit der wirkung von bupivacain und ropivacain an herzen in vitro-untersuchungen zur wirkung der lokalanasthetika aut die kontraktionskraft und das aktionspotential an linken meerschweinchelatrien. Anaesthesist 1993, 42: 516-520.
Mc Clure JH. Ropivacaine. British Journal of Anesthesia 1996; 76: 300-7.
Morrison LM, Emanuelsson BN, Mc Clure JH, et al. Efficacy and kinetics of extradural ropivacaine: comparison with bupivacaine. British Journal of Anesthesia 1994; 72: 164-9.
Whizar-Lugo VM, Carrada-Pérez S. Ropivacaína: una novedosa alternativa en anestesia regional. Rev Mex Anest. 1999; 22: 122-152.