medigraphic.com
ISSN 0016-3813 (Print)

2008, Number 3

<< Back Next >>

Gac Med Mex 2008; 144 (3)

Asociación de la tuberculosis pulmonar con los antígenos del sistema HLA en el Noreste de México

Rojas-Alvarado MÁ, Díaz-Mendoza ML, Said-Fernández S, Caballero-Olíne G, Cerda-Floresa RM

Language: Spanish
References: 35
Page: 233-238
PDF size: 53.09 Kb.


ABSTRACT

Background: Genetic susceptibility to pulmonary tuberculosis (PTb) has been associated with the HLA (Antigens of the Human Leukocytes) system of the MHC (Major Histocompatibility Complex), mainly with HLA-DR and-DQ antigens. Based on this assumption we carried out a case control study to determine the association of PTb with the HLA-DR and-DQ antigens among a sample of patients attending a medical unit belonging to the Mexican Social Security System (IMSS).
Methods: HLA system phenotypes from cases (n=50) and controls (n=417), were defined serologically using a complement dependent microlymphocytotoxic assay. B lymphocytes were obtained using immunobeads. The allele and haplotype frequencies were determined using the Arlequin version 3.01 computer software. Relative risk (RR) was calculated with the Epimax Table Calculator.
Results: The alelles HLA-DR11(5), -DR16(2) and -DQ7(3) and haplotypes /DR11(5)-DQ7(3), /DR14(6)-DQ5(1) and /DR16(2)-DQ7(3) had a higher frequency in cases than in controls (RR›1, p‹0.05). The HLA-DR17(3) and DQ8(3) alelles and /DR17(3)-DQ2 and /DR4-DQ8(3) haplotypes had a higher frequency among controls than among cases (RR‹1, p‹0.05).
Conclusions: These results indicate an association between PTb with the HLA-DR and -DQ antigens in a Mexican sample. Our results are similar to those found in the international literature.


REFERENCES

  1. Bloom BR, Murray CJL. Tuberculosis: commentary on a reemergent killer. Science 1992;257:1055-1064.

  2. WHO. Stop TB, Annual Report 2001. Geneve, Switzwerland: WHO; 2002. pp. 1-17.

  3. Centers for Disease Control. Estimates of future global tuberculosis morbidity and mortality. MMWR 1993;42:961-964.

  4. World Health Organization -GTB. WHO global tuberculosis programme. World TB day. WHO report on the TB epidemic 1996.

  5. Gey van Pittius NC, Sampson SL, Lee H, Kim Y, van Helden PD, Warren RM. Evolution and expansion of the Mycobacterium tuberculosis PE and PPE multigene families and their association with the duplication of the ESAT-6 (esx) gene cluster regions. BMC Evol Biol 2006;6:95.

  6. Meyer CG, May J, Stark K. Human leukocyte antigens in tuberculosis and leprosy. Trends Microbiol 1998;6:148-154.

  7. Chukanova VP, Litvinov VI, Pospelov LE, Slogotskaia LV. Significance of hereditary predisposition factors in the development and course of pulmonary tuberculosis. Vestn Ross Akad Med Nauk 1995;7:6-9.

  8. Knoring BE, Berkoz AS, Sakharova lIa. Distribution of histocompatibility antigens in patients with pulmonary tuberculosis depending on disease course and immune response pattern. Probl Tuberk 1995;2:16-19.

  9. Dovgaliuk IF, Vatutina VV, Kuz’mina SI, Korolenok OL. Clinical and immunogenetic aspects of children with local and multiple forms of primary tuberculosis. Probl Tuberk 1995;5:24-27.

  10. Bothamley GH, Gibbs JH, Beck JS, Schreuder GM, de Vries RR, Grange JM, et al. Delayed hypersensitivity and HLA in smear-positive pulmonary tuberculosis. Int Arch Allergy ImmunoI 1995;106:38-45.

  11. Dubaniewicz A. HLA-DR antigens in patients with pulmonary tuberculosis in northern Poland. Preliminary report. Arch Immunol Ther Exp 2000;48:47-50.

  12. Dubaniewicz A, Moszkowska G, Szczerkowska Z. Frequency of DRB1-DQB1 two-Iocus haplotypes in tuberculosis: preliminary report. Tuberculosis 2005;85:259-267.

  13. Fedoseeva SV, lusopova MM, Chukanova VP, Pospelov LE. Course of infiltrating pulmonary tuberculosis depending on the patient’s genotype. Probl Tuberk 1993;2:8-10.

  14. Goldfeld AE, Delgado JC, Thim S, Bozon MV, Uglialoro AM, Turbay D, et al. Association of an HLA-DQ allele with clinical tuberculosis. JAMA 1998;279:226-228.

  15. Liu ZH, Luo YL, Zhou L, Xu WH, Feng DY, Tan YJ, et al. A study on the correlation between HLA-DR genes and susceptibility to pulmonary tuberculosis in a population of Han nationality from southern China. Zhonghua Jie He He Hu Xi Za Zhi 2004;27:390-393.

  16. Matrashkin AG, Mes’ko EM, Pospelov LE, Eremeev VV, Khaiby SB, Chistiakova NI. Examining the distribution of HLA antigens in patients with tuberculosis and in healthy individuals in the Erza District, Republic of Tyva. Probl Tuberk 2002;12:15-16.

  17. Mehra NK, Rajalingam R, Mitra DK, Taneja V, Giphart MJ. Variants of HLA-DR2/DR51 group haplotypes and susceptibility to tuberculoid leprosy and pulmonary tuberculosis in Asian Indians. Int J Lepr Other Mycobact Dis 1995;63:241-248.

  18. Pospelova LE, Matrashkin AG, Larionova EE, Eremeev VV, Mes’ko EM. The association of tuberculosis with the specificities of the HLA gene DRB1 in different regions of Tuva. Probl Tuberk Bolezn Legk 2005;7:23-25.

  19. Rajalingam R, Mehra NK, Jain RC, Myneedu VP, Pande JN. Polymerase chain reaction-based sequence-specific oligonucleotide hybridization analysis of HLA class II antigens in pulmonary tuberculosis: relevance to chemotherapy and disease severity. J Infect Dis 1996;173:669-676.

  20. Ravikumar M, Dheenadhayalan V, Rajaram K, Lakshmi SS, Kumaran PP, Paramasivan CN, et al. Associations of HLA DRB1, DQB1 and DPB1 with pulmonary tuberculosis in South India. Tuber Lung Dis 1999;79:309-317.

  21. Selvaraj P, Uma H, Reetha AM, Kurian SM, Xavier T, Prabhakar R, et al. HLA antigen profile in pulmonary tuberculosis patients and their spouses. Indian J Med Res 1998;107:155-158.

  22. Sharma SK, Turaga KK, Balamurugan A, Saha PK, Pandey RM, Jain NK, et al. Clinical and genetic risk factors for the development of multi-drug resistant tuberculosis in non-HIV infected patients at a tertiary care center in India: a case-control study. Infect Genet Evol 2003;3:183-188.

  23. Terán-Escandón D, Terán-Ortiz l, Camarena-Olvera A, González-Ávila G, Vaca-Marín MA, et al. Human leukocyte antigen-associated susceptibility to pulmonary tuberculosis: molecular analysis of class II alleles by DNA amplification and oligonucleotide hybridization in Mexican patients. Chest 1999;115:428-433.

  24. Vejbaesya S, Chierakul N, Luangtrakool K, Srinak D, Stephens HA. Associations of HLA class II alleles with pulmonary tuberculosis in Thais. Eur J Immunogenet 2002;29:431-44.

  25. Wang J, Song C, Wang S. Association of HLA-DRB1 genes with pulmonary tubercuiosis. Zhonghua Jie He He Hu Xi Za Zhi 2001;24:302-305.

  26. Cox RA, Downs M, Neimes RE, Ognibene AJ, Yamashita TS, Ellner JJ. Immunogenetic analysis of human tuberculosis. J Infect Dis 1988;158:1302-1308.

  27. Velasco-Rodríguez VM, Martínez-Ordaz VA, Roiz-Hernández J, Huazano-García F, Nieves-Rentería A. Muestreo y tamaño de muestra. Una guía práctica para personal de salud que realiza investigación. 1a. edición virtual y en papel. Buenos Aires, Argentina: E-libro.net; 2003.

  28. Coggon D, Rose G, Barker DJP. Epidemiology for the uninitiated. 4th edition: London, UK: BMJ Publishing Group; 1997.

  29. Master RN. Mycobacteriology. En: Isenberg HD, editor. Clinical microbiology. Procedures handbook. Washington DC: American Society for Microbiology; 1994.

  30. G Kvalheim, Fodstad O, Pihl A, Nustad K, Pharo A, Ugelstad J, et al. Elimination of B-lymphoma cells from human bone marrow: model experiments using monodisperse magnetic particles coated with primary monoclonal antibodies. Cancer Res 1987;47:3846-851.

  31. Terasaki PI, McClelland JD. Microdoplet assay of human serum cytotoxin. Nature 1964;204:998-999.

  32. Mehra NK, Verduijn W, Taneja V, Drabbels J, Singh SP, Giphart MJ. Analysis of HLA-DR2-associated polymorphisms by oligonucleotide hybridization in an Asian Indian population. Hum Immunol 1991;32:246-253.

  33. Lombard Z, Dalton DL, Venter PA, Williams RC, Bornman L. Association of HLA-DR, -DQ, and vitamin D receptor alleles and haplotypes with tuberculosis in the Venda of South Africa. Hum Immunol 2006;67:643-654.

  34. Tiercy JM, Marsh SGE, Schreuder GMTh, Albert E, Fischer G, Wassmuth R. (European Federation for Immunogenetics Subcommittee for Reporting HLA Ambiguities). Guidelines for nomenclature usage in HLA reports: ambiguities and conversion to serotypes. Eur J Immunogenet 2002;29:273-274.

  35. Dubaniewicz A, Moszkowska G, Szczerkowska Z, Hoppe A. Analysis of DQB1 allele frequencies in pulmonary tuberculosis: preliminary report. Thorax 2003;58:890-891.




2020     |     www.medigraphic.com