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2004, Number 3

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Bioquimia 2004; 29 (3)

Short review: Role of cell-mediated inmunity in amoebiasis resolved

Pertuz BSB, Flores RL

Language: Spanish
References: 54
Page: 91-98
PDF size: 91.44 Kb.


ABSTRACT

The immune response effective against Entamoeba histolytica has not been completely described. Cell-mediated immunity has been linked to resistance to amebiasis. Neutrophils and macrophages are the cells involved in the destruction of Entamoeba histolytica. Generation of oxygen mediators by macrophages has been documented as a destruction mechanism for Entamoeba histolytica. Other cells from the immune system, such as eosinophils, have also been linked to the resistance of infection. Generation of cytokines and chemokines by macrophages, neutrophils, lymphocytes and epithelial cells not only guide the migration of cells charged with destroying the parasite, but also arrange for the immune response that will lead to an effective resolution of infection. In this sense, we cannot conclude about the cellular immunity against this parasite because the results are subject to the variability of the models used. The objective of this review is to conclude which is the cellular immunity response that contributes to solve the infection by Entamoeba histolytica.


REFERENCES

  1. Stanley Jr S. Amoebiasis. Lancet 2003; 361: 1025-1034.

  2. Petri WA, Haque R, Lyerly D, Vines RR. Estimating the impact of amebiasis on health. Parasitology Today 2000; 16: 320-321.

  3. Jackson T, Reddy S, Fincham J, Abd-Alla M, Welles S, Ravdin J. A comparison of cross-sectional and longitudinal seroepidemiological assessments of Entamoeba-infected population in South Africa. Arch Med Res 2000; 31(Suppl): S36-S37.

  4. Gatti S, Swierczynski J, Cevini C, Bruno A, Anselmi M, Bisoffi Z, et al. Incidence of amebic infection in a village of Northern Ecuador. Arch Med Res 2000; 31(Suppl): S38-S40.

  5. Sánchez-Guillén MC, Pérez-Fuentes R, Salgado-Rosas H, Ruiz-Argüelles A, et al. Differentiation of Entamoeba histolytica/Entamoeba dispar by PCR and their correlation with humoral and cellular immunity in individuals with clinical variants of amoebiasis. Am J Trop Med Hyg 2002; 66: 731-737.

  6. Ramos F, Valdez E, Morán P, González E, Padilla G, Gómez A, Ramiro M, et al. Prevalence of Entamoeba histolytica and Entamoeba dispar in a highly endemic rural population. Arch Med Res 2000; 31(Suppl): S34-S35.

  7. Morales-Espinoza EM, Sánchez-Pérez HJ, García-Gil MM, Vargas-Morales G, Méndez-Sánchez JD, Pérez-Ramírez M. Intestinal parasites in children, in highly deprived areas in the border region of Chiapas, Mexico. Salud Publica Mex 2003; 45: 379-388.

  8. Blessmann J, Ali IK, Nu PA, Dinh BT, Viet TQ, Van AL, et al. Longitudinal study of intestinal Entamoeba histolytica infections in asymptomatic adult carriers. J Clin Microbiol 2003; 41: 4745-4750.

  9. Abd-Alla M, Wahib A, Ravdin J. Comparison of antigen-capture ELISA to stool-culture methods for the detection of asymptomatic Entamoeba species infection in Kafer Daoud, Egypt. Am J Trop Med Hyg 2000; 62: 579-582.

  10. Beving DE, Soong CJ, Ravdin JI. Oral immunization with a recombinant cysteine-rich section of the Entamoeba histolytica galactose-inhibitable lectin elicits an intestinal secretory immunoglobulin A response that has in vitro adherence inhibition activity. Infect Immun 1996; 64: 1473-1476.

  11. Zhang T, Li E, Stanley SL. Oral immunization with the dodecapeptide repeat of the serine-rich Entamoeba histolytica protein (SREHP) fused to the cholera toxin B subunit induces a mucosal and systemic anti-SREHP antibody response. Infect Immun 1995; 63: 1349-1355.

  12. Zhang T, Stanley SL. Oral immunization with an attenuated vaccine strain of Salmonella typhimurium expressing the serine-rich Entamoeba histolytica protein induces an antiamebic immune response and protects gerbils from amebic liver abscess. Infect Immun 1996; 64: 1526-1531.

  13. Huston CD, Petri WA. Host-pathogen interaction in amebiasis and progress in vaccine development. Eur J Clin Microbiol Infect Dis 1998; 17: 601-614.

  14. Houpt E, Barroso L, Lockhart L, Wright R, Cramer C, Lyerly D, et al. Prevention of intestinal amebiasis by vaccination with the Entamoeba histolytica Gal/GalNac lectin. Vaccine 2004; 22: 612-618.

  15. Stanley S, Reed S. Microbes and microbial toxins: Paradigms for microbial-mucosal interactions. VI. Entamoeba histolytica: parasite-host interactions. Am J Physiol Gastrointest Liver Physiol 2001; 280: G1049-G1054.

  16. Espinosa-Cantellano M, Martínez-Palomo A. Pathogenesis of intestinal amebiasis: from molecules to disease. Clin Microbiol Rev 2000; 13: 318-331.

  17. Seydel K, Zhang T, Stanley JR. Neutrophils play a critical role in early resistence to amebic liver abscesses in severe combined immunodeficient mice. Infect Immun 1997; 65: 3951-3953.

  18. Velazquez C, Shibayama-Salas M, Aguirre-García J, Tsutsumi V, Calderon J. Role of neutrophils in innate resistance to Entamoeba histolytica liver infection in mice. Parasite Immunol 1998; 20: 255-262.

  19. Ghosh P, Ventura J, Gupta S, Serrano J, Tsutsumi V, Ortiz-Ortiz L. Experimental amebiasis: Immunohistochemical study of immune cell populations. J Eukaryot Microbiol 2000; 47: 395-399.

  20. Seydel KB, Li E, Swanson PE, Stanley SL Jr. Human intestinal epithelial cells produce pro-inflammatory cytokines in response to infection in a SCID mouse-human intestinal xenograft model of amebiasis. Infect Immun 1997; 65: 1631-1639.

  21. Seydel KB, Li E, Zhang Z, Stanley SL Jr. Ephitelial cell-initiated inflammation plays a crucial role in early tissue damage in amebic infection of human intestine. Gastroenterology 1998; 115: 1446-1453.

  22. Rivero-Nava L, Aguirre-García J, Shibayama-Salas M, Hernández-Pando R, Tsutsumi V, Calderón J. Entamoeba histolytica: acute granulomatous intestinal lesions in normal and neutrophil-depleted mice. J Exp Parasitol 2002; 10: 183-192.

  23. Seydel K, Smith S, Stanley SL Jr. Innate immunity to amebic liver abscess is dependent on gamma interferon and nitric oxide in murine model of disease. Infect Immun 2000; 68: 400-402.

  24. Jarillo-Luna RA, Campos-Rodríguez R, Tsutsumi V. Entamoeba histolytica: immunohistochemical study of hepatic amoebiasis in mouse. Neutrophils and nitric oxide as possible factors of resistance. Exp Parasitol 2002; 101: 40-56.

  25. Salata R, Murray H, Rubin B, Ravdin J. The role of interferon in the generation of human macrophages cytotoxic for Entamoeba histolytica trophozoites. Am J Trop Med Hyg 1987; 37: 72-78.

  26. Jarrillo-Luna RA, Campos-Rodríguez R, Tsutsumi V. Participation of neutrophils, macrophages and endotelial cells in the amebic liver lesion in the mouse. Arch Med Res 2000; 31(Suppl): S101-S103.

  27. García MI, Rocha LM, Ramírez A, Santos JI. Macrophage colony-stimulating factor enhances the respiratory Bursa of human monocytes in response to Entamoeba histolytica. Arch Med Res 1992; 23: 139-140.

  28. Murray HW, Aley SB, Scott WA. Susceptibility of Entamoeba histolytica to oxygen intermediates. Mol Biochem Parasitol 1981; 3: 381-391.

  29. Ghadirian E, Somerfield SD, Kongshavn PAL. Susceptibility of Entamoeba histolytica to oxidants. Infect Immun 1986; 51: 263-267.

  30. Morán P, Rico G, Ramiro M, Olvera H, Ramos F, González E, et al. Defective production of reactive oxygen intermediates (ROI) in a patient with recurrent amebic liver abscess. Am J Med Hyg 2002; 67: 632-635.

  31. Denis M, Chadee K. In vitro and in vivo studies of macrophage functions in amebiasis. Infect Immun 1988; 56: 3126-3131.

  32. Wang W, Keller K, Chadee K. Modulation of tumor necrosis factor production by macrophages in Entamoeba histolytica infection. Infect Immun 1992; 60: 3169-3174.

  33. Denis M, Chedee K. Cytokine activation of murine macrophages for in vitro killing of Entamoeba histolytica trophozoites. Infect Immun 1989; 57: 1750-1756.

  34. Lin JY, Seguin R, Keller K, Chadee K. Tumor necrosis factor alpha augments nitric oxide-dependent macrophage cytotoxicity against Entamoeba histolytica by enhanced expression of the nitric oxide synthase gene. Infect Immun 1994; 62: 1534-1541.

  35. Kretschmer R, Rico G, Giménez JA. A novel anti-inflammatory oligopeptide produced by Entamoeba histolytica. Mol Biochem Parasitol 2001; 112: 201-209.

  36. Salata RA, Cox JG, Ravdin JL. The interaction of human T-lymphocytes and Entamoeba histolytica: killing of virulent amoeba by lectin-dependent lymphocytes. Parasite Immunol 1987; 9: 249-261.

  37. Salata RA, Martínez-Palomo A, Murray HW, Conales L, Treviño N, Segovia E, et al. Patients treated for amebic liver abscess develop cell-mediated immune mechanisms effective in vitro against Entamoeba histolytica. J Immunol 1986; 136: 2633-2639.

  38. Vohra H, Kaur U, Sharma AK, Bhalla V, Bhasin D. Effective human defense against E. histolytica: high amoebicidal activity of lymphocytes and monocytes in amoebic liver abscess patients until 3 months follow-up. Parasitol Int 2003; 2: 193-202.

  39. Houpt ER, Glembocki DJ, Obrig TG, Moskaluk CA, Lockhart, LA, Whight RL, et al. The mouse model of amebic colitis reveals mouse strain susceptibility to infection and exacerbation of disease by CD4+ T cells. J Immunol 2002; 169: 4496-4503.

  40. Talámas-Rohana P, Schilie-Guzmán MA, Hernández-Ramírez V, Rosales-Encina JL. T-Cell suppression and selective in vivo activation of TH2 subpopulation by Entamoeba histolytica 220-Kilodalton lectin. Infect Immun 1995; 63: 3953-3958.

  41. López OM, Arellano J, Kretschmer R. The destruction of virulent Entamoeba histolytica by activated human eosinophils. Parasite Immunol 1992; 14: 579-586.

  42. López-Osuna M, Velázquez JR, Kretschmer RR. Does the eosinophil have a protective role in amebiasis? Mem Inst Oswaldo Cruz 1997; 92: 237-240.

  43. Tsutsumi V, Martínez-Palomo A. Inflammatory reaction in experimental hepatic amebiasis. An ultrastructural study. Am J Pathol 1988; 130: 112-119.

  44. Navarro-García F, Lopez RR, Vega LM, Domínguez RM, Enriquez RF, Tsutsumi V. Intragastric immunization of rats with Entamoeba histolytica trophozoites induces cecal mucosal IgE, eosinophilic infiltration and type hypersensitivity. Clin Immunol Immunopathol 1997; 82: 221-229.

  45. Kasper LL, Buzoni-Gatel D. Ups and downs of mucosal cellular immunity against protozoan parasites. Infect Immun 2001; 69: 1-8.

  46. Séguin R, Mann B, Keller K, Chadee K. TNF-a-stimulating region of galactose-inhibitable lectin of Entamoeba histolytica activates gamma interferon-primed macrophages for amebicidal activity mediated by nitric oxide. Infect Immun 1997; 65: 2522-2527.

  47. Zhang Z, Mahajan S, Zhang X, Stanley SL Jr. Tumor necrosis factor alpha is a key mediator of gut inflammation seen in amebic colitis in human intestine in the SCID mouse-human intestinal xenograft model of disease. Infect Immun 2003; 71: 5355-5359.

  48. Campbell D, Chadee K. IL-2, IL4, and TNF-a responses during Entamoeba histolytica liver abscess development in gerbils. J Infect Dis 1997; 175: 1176-1183.

  49. Campbell D, Mann B, Chadee K. A subunit vaccine candidate region of the Entamoeba histolytica galactose-adherence lectin promotes interleukin-12 gene transcription and protein production in human macrophages. Eur J Immunol 2000; 30: 423-430.

  50. Flores-Romo L, Estrada-García T, Shibayama-Salas M, Campos-Rodríquez R, Bacon K, et al. In vitro Entamoeba histolytica adhesion to human endotelium: a comparison using two strains of different virulence. Parasitol Res 1997; 83: 397-400.

  51. Seydel K, Li E, Swanson P, Stanley S. Human intestinal epithelial cells produce proinflammatory cytokines in response to infection in a SCID mouse-human intestinal xenograft model amebiasis. Infect Immun 1997; 65: 1631-1639.

  52. Yu Yi, Chadee K. Entamoeba histolytica stimulates interleukin 8 from human colonic epithelial cells without parasite-enterocyte contact. Gastroenterology 1997; 112: 1536-1547.

  53. Eckman L, Reed S, Smith J, Kagnoff M. Entamoeba histolytica trophozoites induce an inflammatory cytokine response by cultured human cells through the paracrine action of cytolytically interleukin-1a. J Clin Invest 1995; 96: 1269-1279.

  54. Dwinell MB, Johanesen P, Smith J. Immunobiology of epithelial chemokines in the intestinal mucosa. Surgery 2003; 133: 601-607.




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