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Instituto Nacional de Salud Pública

2003, Number S3

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salud publica mex 2003; 45 (S3)

Prospects for primary prevention of cervical cancer in developing countries

Franceschi S, Clifford G, Plummer M

Language: English
References: 31
Page: 430-436
PDF size: 88.30 Kb.


ABSTRACT

The HPV types that cause cervical cancer are sexually transmitted,but there is little evidence that infection can be avoided by behavioural changes, such as condom use. In contrast, prophylactic vaccines against HPV infection are likely to have high efficacy. In principle, the effectiveness of HPV vaccination as a strategy for cervical cancer control can be measured either by monitoring secular trends in cervical cancer incidence or by conducting randomized trials. The former approach is unlikely to provide convincing evidence of effectiveness, since cervical cancer rates are subject to strong secular trends that are independent of intervention measures. A few phase III trials of HPV prophylactic vaccines are now being started. Such trials are very expensive studies involving frequent and complicated investigations. It is important, however, to start as soon as possible simpler trials designed to demonstrate the effectiveness of HPV vaccine in field conditions, i.e. in developing or intermediate countries which suffer the major burden of mortality from cervical cancer. Such trials may capture a difference in the most severe, and rarest, preinvasive cervical lesions (i.e., the real target of any HPV vaccine) over a prolonged follow-up (20 years at least). The design of such studies is briefly considered for two areas: Southern India and South Korea.


REFERENCES

  1. Pisani P, Parkin DM, Bray F, Ferlay J. Estimates of the worldwide mortality from 25 cancers in 1990. Int J Cancer 1999;83:18-29.

  2. Sherris J, Herdman C. Preventing cervical cancer in low-resource settings. Outlook 2000;18:1-8.

  3. Sankaranarayanan R, Budukh AM, Rajkumar R. Effective screening programmes for cervical cancer in low- and middle-income developing countries. Bull World Health Organ 2001;79:954-962.

  4. Wesley R, Sankaranarayanan R, Mathew B, Chandralekha B, Aysha Beegum A, Amma NS et al. Evaluation of visual inspection as a screening test for cervical cancer. Br J Cancer 1997;75:436-440.

  5. Sankaranarayanan R, Wesley R, Somanathan T, Dhakad N, Shyamalakumary B, Amma NS et al. Visual inspection of the uterine cervix after the application of acetic acid in the detection of cervical carcinoma and its precursors. Cancer 1998;83:2150-2156.

  6. International Agency for Research on Cancer. Monographs on the evaluation of carcinogenic risks to humans. Human papillomaviruses. IARC: Lyon, 1995;Vol. 64.

  7. Walboomers JM, Jacobs MV, Manos MM, Bosch FX, Kummer JA, Shah KV et al. Human papillomavirus is a necessary cause of invasive cervical cancer worldwide. J Pathol 1999;18:12-19.

  8. Herrero R, Hildesheim A, Bratti C, Sherman M, Hutchinson M, Morales J et al. A population-based study of human papillomavirus infection and cervical neoplasia in rural Costa Rica. J Natl Cancer Inst 2000;92:464-474.

  9. Lazcano-Ponce E, Herrero R, Muñoz N, Cruz A, Shah KV, Alonso P et al. Epidemiology of HPV infection among Mexican women with normal cervical cytology. Int J Cancer 2001;91:412-420.

  10. Franceschi S, Castellsagué X, Dal Maso L, Smith JS, Plummer M, Ngelangel C et al. Prevalence and determinants of human papillomavirus genital infection in men. Br J Cancer 2002;86:705-711.

  11. Molano M, Posso H, Weiderpass E, van den Brule AJC, Ronderos M, Franceschi S et al. Prevalence and determinants of HPV infection among Colombian women with normal cytology. Br J Cancer. 2002;87:324-333.

  12. Castellsagué X, Bosch FX, Muñoz N, Meijer C, Shah K, de Sanjosé S, Eluf-Neto J et al. Male circumcision, penile human papillomavirus infection and cervical cancer in female partners. N Engl J Med 2002;346:1105-1112.

  13. Muñoz N, Franceschi S, Bosetti C, Moreno V, Herrero R, Smith JS et al. Role of parity and human papillomavirus in cervical cancer: The IARC multicentric case-control study. Lancet 2002;359:1093-1101.

  14. Moreno V, Bosch FX, Muñoz N, Meijer CJ, Shah KV, Walboomers JM et al. Effect of oral contraceptives on risk of cervical cancer in women with human papillomavirus infection: The IARC multicentric casecontrol study. Lancet 2002;359:1085-1092.

  15. Plummer M, Herrero R, Franceschi S, Meijer CJLM, Snijders P, Bosch FX et al. Smoking and cervical cancer: Pooled analysis of are a multicentric case-control study. Cancer Causes R Control. In press.

  16. Smith JS, Herrero R, Bosetti C, Muñoz N, Bosch FX, Eluf-Neto J et al. Herpes simplex virus-2 as a human papillomavirus cofactor in the etiology of invasive cervical cancer. J Natl Cancer Inst. 2002;94:1604-1613.

  17. Smith JS, Muñoz N, Bosetti C, Herrero R, Bosch FX, Eluf-Neto J et al. Chlamydia trachomatis as an HPV cofactor in the etiology of invasive cervical cancer: A pooled analysis of seven countries. 19th International Papillomavirus Conference; 2001;Florianopolis, Brazil. O-135.

  18. Kols A, Sherris J. HPV Vaccines: Promise and challenges. Seattle (WA): PATH, 2000.

  19. Harro CD, Pang YY, Roden RB, Hildesheim A, Wang Z, Reynolds MJ et al. Safety and immunogenicity trial in adult volunteers of a human papillomavirus 16 L1 virus-like particle vaccine. J Natl Cancer Inst 2001;21: 284-292.

  20. Clifford GM, Smith JS, Plummer M, Muñoz N, Franceschi S. Human papillomaviruses in invasive cervical cancer worldwide: A meta-analysis. J Natl Cancer Inst Br J. Cancer 2003;88:63-73.

  21. Evans TG, Bonnez W, Rose RC, Koenig S, Demeter L, Suzich JA et al. A phase 1 study of a recombinant viruslike particle vaccine against human papillomavirus type 11 in healthy adult volunteers. J Infect Dis 2001;183:1485-1493.

  22. Koutsky LA, Wheeler Cm, Brown DR, Barr E, Alvarez FB, Chiacchierini LM et al. A controlled trial of a human papillomavirus type 16 vaccine. N Engl J Med 2002;347:1645-1651.

  23. Franceshi S. Strategies to reduce the risk of virus-related cancers. Ann Oncol 2000;11:1091-1096.

  24. International Agency for Research on Cancer. Monographs on the evaluation of carcinogenic risks to humans. Hepatitis viruses. IARC: Lyon, 1994; Vol. 59.

  25. Gambia Hepatitis Study Group. The Gambia hepatitis intervention study. Cancer Res 1987;47:5782-5787.

  26. Viviani S, Jack A, Hall AJ, Maine N, Mendy M, Montesano R et al. Hepatitis B vaccination in infancy in The Gambia: Protection against carriage at 9 years of age. Vaccine 1999;17:2946-2950.

  27. Huang K, Lin S. Nationwide vaccination: A success story in Taiwan. Vaccine 2000;18 (Suppl 1):S35-S38.

  28. Beral V, Hermon C, Muñoz N, Devesa SS. Cervical cancer. Cancer surv 1994;19/20:265-285.

  29. Parkin DM, Whelan SL, Ferlay J, Raymond L, Young J. Cancer incidence in five continents. International Agency for Research on Cancer, Lyon: Vol. VII; IARC Scientific publications No 143. 1997.

  30. Konya J, Dillner J. Immunity to oncogenic human papillomaviruses. Adv Cancer Res 2001;82:205-238.

  31. Nardelli-Haefliger D, Wirthner D, Schiller J, Lowy DR, Hildesheim A, Ponci F. Specific antibody levels at the cervix during menstrual cycle of women vaccinated with human papillomavirus 16 virus like particles. J Natl Cancer Inst 2003;95:1128-1137.




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