Morales MG, Aguirre SJ, Poblano MM, Martínez SJ, Sánchez CC

Language: Spanish
References: 10
Page: 143-148
PDF size: 113.98 Kb.

ABSTRACT

Introduction: The Procalcitonin (PCT) is known for its power to diagnose sepsis; there are few studies that compare the PCT quantitative versus semi-quantitative, we made this study to evaluate this correlation.
Objective: To evaluate the correlation between determination of the quantitative and semiquantitative PCT in the early diagnosis of sepsis in the Intensive Care Unit (ICU).
Design: Prospective, longitudinal, double blind.
Setting: Medical-surgical ICU.
Patients: Thirty patients divided in 2 groups: A) 16 patients with SIRS and B) 14 patients with sepsis admitted to UCI during a period of 7 months.
Measures and main results: The samples were obtained at admission, 24, 48 and 72 hours and thereafter every 48 hours, until completing a maximum of 6 samples. Sepsis of bacterial origin was considered when determinations of PCT were ≥ 0.5 ng/mL. We made 180 pairs of determinations with the analysis of correlation between the quantitative and semiquantitative PCT with a global r = 0.62, with p ‹ 0.001.
Conclusion: There were well correlation between determination of the quantitative and semiquantitative PCT and its correlation is greater when its plasmatic level is higher.

REFERENCES

1. Morales MG, Ruiz AM, Aguirre SJ et al. Procalcitonina en el diagnóstico temprano de sepsis de origen bacteriano. Med Crit y Ter Int 2006;20(2):57-64.

2. Christ-Crains M, Müller B. Procalcitonin on the dusty way to the holy grail: A progress report. In Yearbook of intensive care and emergency medicine. Edited by Vicent JL. Berlin: Springer-Verlag; 2005:461-76.

3. Becker KL, O´Neill WL, Snider R, Nylen E. Moore CF, Jeng J et al. Hyperprocalcitoninemia in inhalation burn injury: a response of the pulmonary neuroendrocrine cell? Anat Rec 1993;236:136-38.

4. Bone RC, Sibbald WJ, Sprung CL. The ACCP-SCCM consensus conference on sepsis and organ failure. Chest 1992;101:1481-83.

5. Mclean AS, Tang B, Huang SJ. The diagnosis of sepsis: The present and the future. Yearbook of intensive care and emergency medicine 2007. Edited by Vicent JL. Berlin: Springer-Verlag; 2007:3-9.

6. Jensen JU, Løken J, Mohr T. Procalcitonin: nice to know, need to know, or needs further research? Yearbook of intensive care and emergency medicine 2007. Edited by Vicent JL. Berlin: Springer-Verlag; 2007:10-21.

7. Christ-Crain M, Müller B. Diagnostic and prognostic value of hormokines as biomarkers in severe infections. Yearbook of intensive care and emergency medicine 2007. Edited by Vicent JL. Berlin: Springer-Verlag; 2007:10-21.

8. Pelinka LE, Sendova K, Mauritz et al. Quantitative versus semiquantitative procalcitonin measurement. European Journal of trauma 2003;29(2):81-84.

9. Kordek A, Podraza W, Czajka R. Reliability of semiquantitative determination of procalcitonin serum concentrations in neonates. Diagn Microbiol Infect Dis 2006;56(1):31-34.

10. Korczowski B, Malek U, Kowalczyk JR et al. Two diagnostic assays for serum procalcitonin measurement in clinical practice. Przegl Lek 2003;60(5):345-348.