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Instituto Nacional de Salud Pública

2003, Number 6

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salud publica mex 2003; 45 (6)

DDT/DDE concentrations and risk of hypospadias. A case-control pilot study

Flores-Luévano S, Farías P, Hernández M, Romano-Riquer P, Weber JP, Dewailly E, Cuevas-Alpuche J, Romieu I

Language: Spanish
References: 38
Page: 431-438
PDF size: 98.32 Kb.


ABSTRACT

Objective. To evaluate the association between maternal serum DDT/DDE levels and risk of hypospadias. Material and Methods. A case-control study in Mexico City was conducted during 1997-1999 among 41 subjects with hypospadias and 28 controls. Blood samples were obtained from study subjects. Information was obtained using a standardized questionnaire. Data were analyzed using multivariate logistic regression models. Results. Maternal DDT and DDE levels showed no association with hypospadias (OR 1.13; 95% CI 0.24-5.29 and OR=0.48; 95% CI 0.15-1.60, respectively). Associated factors were older age of mothers (OR 8.69; 95% CI 1.69-44.9), and working during pregnancy (OR 4.68; 95% CI 1.15-18.9). Conclusions. Information about the endocrine effects of different levels of DDT/DDE in human subjects is scarce; dosage may be a determinant factor of the type of effect.


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