2008, Number S1
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Cir Gen 2008; 30 (S1)
Gatrointestinal stromal tumors. Medical treatment
Capdeville GD
Language: Spanish
References: 15
Page: 23-26
PDF size: 61.74 Kb.
ABSTRACT
Gastrointestinal stromal tumours (GIST) are uncommon: they represent 0.2% of the gastrointestinal neoplasms, and they have a subestimated prevalence. Considering the GIST’s potential malignancy, the clinician must consider histopathology, anatomopathology, and immunohistochemistry in order to determine if they are kit-receptor positive, and if the patients are candidates to receive imatinib treatment.
Imatinib mesylate is a well-tolerated treatment, administered orally. It has a mild and moderated toxicity; it is effective for these types of tumours, particularly in patients with irresecable disease and/or non-resectable metastasis. It is advisable to non-resectable and metastasic tumours with daily doses of 400 to 800 mg.
So far, several studies are being carried out to define more accurately the specifications and administration of neoadjuvant and adjuvant treatments.
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