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2008, Number 2

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Ann Hepatol 2008; 7 (2)

Clinical update on non-alcoholic fatty liver disease and steatohepatitis

Bugianesi E, Bellentani S, Bedogni G, Tiribelli C, Svegliati-Baroni G, Crocè LS, Gastaldelli A, Marchesini G, Marra F, Perseghin G, Gianluca Tell G

Language: English
References: 19
Page: 157-160
PDF size: 102.01 Kb.


Text Extraction

Fatty liver or hepatic steatosis is a common and often occasional finding for the general practitioner. After exclusion of less common causes of fatty liver such as Hepatitis B or C infection, drugs and autoimmune disorders, fatty liver is classified as non-alcoholic (NAFLD) or alcoholic fatty liver disease (AFLD) on the basis of daily ethanol intake. The agreed threshold of ethanol intake used to separate NAFLD from AFLD is 20 g/day, equivalent to 12 drinks per week. The term NAFLD covers a wide spectrum of liver injury, ranging from simple steatosis, i.e. fatty infiltration of hepatocytes › 5%, to non-alcoholic steatohepatitis (NASH). At liver biopsy NASH is characterized by necro-inflammation and/or fibrosis, and is histologically indistinguishable from alcoholic steatohepatitis. The histological classification of NAFLD and NASH is being continuously improved and a refined scoring system has been recently proposed by the National Institutes of Health.


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