Bennett-Guerrero E

Language: English
References: 22
Page: 97-100
PDF size: 94.10 Kb.

Text Extraction

Although the mortality rate for major surgery is low (1-5%), postoperative morbidity is common (10-20%). Complications include cardiac and non-cardiac related etiologies such as infection, gastrointestinal dysfunction, acute lung injury, stroke, and renal dysfunction. Many postoperative complications appear to be caused by an exaggerated systemic pro-inflammatory response to surgical trauma. The systemic inflammatory response syndrome (SIRS) refers to an inflammatory process that can arise from or in the absence of infection. The systemic elaboration of inflammatory mediators may be beneficial by heightening the host’s general defenses. It, however, may lead to the «autodestruction» of the host through secondary damage to tissues/organs not originally affected by the primary injury or infection. The most severe form of this inflammatory response leads to multiple organ dysfunction syndrome and death. Milder forms of a pro-inflammatory response cause less severe organ dysfunction which do not lead to admission to an intensive care unit, but nevertheless cause suffering, increased hospital length of stay, and increased cost.

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