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2008, Number 2

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Rev Mex Anest 2008; 31 (2)

Sugammadex New alternative for to revert the muscle relaxing

Carrillo-Esper R, Sánchez-García R, Jiménez-Morales EE

Language: Spanish
References: 29
Page: 139-145
PDF size: 181.25 Kb.


ABSTRACT

Cyclodextrins are large molecules of various numbers of glucose molecules bound in a ring-like structure. This creates a hydrophilic outer layer with a lipophilic inner core. Sugammadex is a modified cyclodextrin designed to encapsulate aminosteroid nondepolarizing muscle relaxing agents. It has been successfully tested in animals and humans. It has been shown to be well tolerated and effective in humans. Sugammadex binds neuromuscular blocking agents and encapsulates them, making cholinesterase inhibitors unnecesary. Due to its rapid onset of action and relative lack of side effects, this drug promises to change the method of anesthesia delivery. This review summarizes the literature of the drug.


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