Zavala-Villeda JA, Hernández-Reyna VE, Molina-Méndez FJ, Rojas-Pérez EM, Fernández-Rivera B, Vargas-Trujillo C

Language: Spanish
References: 15
Page: 84-87
PDF size: 100.95 Kb.

ABSTRACT

Objective: Evaluate if there is a direct relationship between the way of administration of heparin and the presence of hemodynamic and hydroelectrolitic changes in patients who underwent revascularization surgery in the Instituto Nacional de Cardiología «Ignacio Chávez». Methods: 26 patients were included in this study underwent revascularization surgery with extracorporeal circulation. Group DB we give 300 U/kg of heparin in bolus through the central catheter. Group DF we give 300 U/kg of fractionated heparin in three equivalent doses with an interval of one minute through of central catheter. A measurement of CO, CI, SVR, PVR, MPP, HR, MAP, potassium and seric calcium by five minutes before administrating the doses and three minutes after, and of activated coagulation time before and after heparin. Results: It was not found significant difference between both groups in gender, age, weight, height, body mass index, superficial corporeal area, LVEF and CARE scale. A decrease of the SVR and MAP was found posterior to the administration in bolus of the dose of heparin p = 0.04, p = 0.002, an increase of serum potassium after the administration in bolus of heparin was found p = 0.005. Conclusions: The administration in bolus of heparine in high doses has important vasodilating properties.

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