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2008, Number 2

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Rev Mex Anest 2008; 31 (2)

Postoperative analgesia with nimesulide vs metamizol in appendicectomies. Random and prospective study

Paz-Estrada C, Rodríguez-López J, Fuentes-Pérez M

Language: Spanish
References: 38
Page: 79-83
PDF size: 84.08 Kb.


ABSTRACT

Antecedents: One of the techniques of preventive analgesia to treat the postoperative pain includes the use of analgesic anti-inflammatory not conventional esteroids. Objective: To compare the postoperative analgesic effectiveness of nimesulide in front of metamizol in appendicectomy. Material and method: We were carried out a controlled clinical rehearsal, in the Hospital «Guillermo Luis Fernández Hernández-Baquero», Holguín, Cuba, during a period of ten months. 88 patients were selected in total, which were divided at random in two groups of 44 patients each one: Group I: nimesulide 200 mg, via oral, 120 minutes before proceeding surgical and Group II: metamizol 2 g intravenous, after the induction of the anesthesia and premedication with midazolam 0.02 mg/kg IV. Apply anesthesia general orotraqueal and registered arterial pressure, heart frequency and saturation of the hemoglobin in several stages of the perioperative as well as the most frequent adverse effects. The intensity of the pain was measured in the postoperative one through the Similar Visual Scale. Results: A decrease of the pain was observed in the postoperative one in both groups, more marked with the patients of the Group II, not being significant at the 6 hours (p = 0.277). The adverse effects found in the Group I: vomits in 2 patients. In the Group II: nauseas in 8 cases and vomits in 6 patients. Conclusions: The nimesulide and metamizol administrations are effective when being used as preventive analgesia in surgery of patient to which was carried out appendicectomy.


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