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2008, Number 1

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Gac Med Mex 2008; 144 (1)

Niveles de moléculas de adhesión solubles en pacientes diabéticos tipo 2 normotensos e hipertensos

Rubio-Guerra AF, Vargas-Robles H, Medina-Santillán R, Escalante-Acosta BA

Language: Spanish
References: 20
Page: 11-14
PDF size: 38.18 Kb.


ABSTRACT

Background: Hypertension and type-2 diabetes affect endothelial function, which in turn increases the expression of soluble adhesion molecules and lead to the development of vascular damage. The aim of this study was to assess soluble adhesion molecule levels among normotensive and hypertensive diabetic patients.
Material and methods: Serum levels of soluble VCAM1, ICAM1 and e-selectin were measured in 80 type-2 diabetic patients, (40 normotensive and 40 hypertensive), and in 40 normotensive nondiabetic subjects by ELISA (RyDSystems Minneapolis). Statistical analysis was performed with ANOVA.
Results: Among diabetic patients, levels of all three soluble adhesion molecules were significantly increased when compared with nondiabetic patients (p ‹ 0.001 for all three molecules), In diabetic hypertensive patients, higher levels of ICAM1 were detected in comparison to normotensive diabetic patients (316 vs. 295 ng/ml p‹ 0.01), VCAM1 and e-selectin levels were not different between diabetic patients with and without hypertension.
Conclusions: Diabetes is associated with increased levels of soluble adhesion molecules, suggesting a role of these molecules may play in endothelial damage. ICAM1 is further increased when hypertension and diabetes are present. The latter may explain why diabetic-hypertensive patients displayed more complications than normotensive patients.


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