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2008, Number 1

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Med Sur 2008; 15 (1)

Coronary artery flow, myocardial dysfunction and sepsis

González-Chon O, García-López S, Arias-Sánchez EA, Arriaga-Gracia J

Language: Spanish
References: 40
Page: 3-10
PDF size: 120.75 Kb.


ABSTRACT

Septic shock is a high cardiac output entity with high oxygen demand and reduced systemic vascular resistance and oxygen supply, secondary to a loss in autoregulation and non homogeneous capillary blood flow. Clinical Studies have suggested that inadequate coronary blood flow plays an important role in cardiac dysfunction related to sepsis. Sepsis has been associated with a diminished global myocardial perfusion that results in ischemic damage and cardiac dysfunction. Hemodynamic pattern in septic patients is characterized by a low systolic volume despite a high cardiac output. Infection induces a great number of inflammatory mediators that amplify septic response and therefore contribute to myocardial dysfunction. Nitric oxide production contributes to this process by the production of cGMP. Nowadays is of primary importance to run clinical assays to better understand myocardial dysfunction in the septic patient as to understand if cardiac dysfunction is a protective process and the therapeutic approach of this disease.


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