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Órgano oficial de difusión de la Federación Mexicana de Patología Clínica, AC y de la Asociación Latinoamericana de Patología Clínica/Medicina de Laboratorio

2008, Number 1

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Rev Mex Patol Clin Med Lab 2008; 55 (1)

Increment in the concentration of nitric oxide and meta-hemoglobin in erythrocytes contents in bags for blood transfusions

Gutiérrez-Salinas J, Cruz-Tovar L, García-Méndez S

Language: Spanish
References: 38
Page: 21-28
PDF size: 117.50 Kb.


ABSTRACT

The transfusion of globular package can represent a risk for the patient that receives it since the metabolism of the erythrocyte during its storage substances that can be responsible for diverse reactions in the organism can take place. In the erythrocytes the nitric oxide can react with hemoglobin to form meta-hemoglobin and nitrates. Both substances contained in the globular package can produce alterations in the human that receives it. Objective: Our objective was to determine if globular packages preserved under normal conditions in a Blood Bank present alterations in the concentration of nitric oxide and meta-hemoglobin along the time. Material and methods: Twelve globular packages were chosen following the routine procedures of the Blood Bank of our institution. Samples of each package were obtained daily for five days and every five days until 30 days. Concentration of total nitrates (as an index of the presence of the nitric oxide) and meta-hemoglobin were determined. Results: An important increment was show in the concentration of total nitrates and meta-hemoglobin along the time in the erythrocytes from globular packages. Conclusions: The increment in the concentration of nitric oxide and meta-hemoglobin in the globular packages it can be a factor that produces adverse reactions in the patient that receives a blood transfusion.


REFERENCES

  1. Bunn HF, May MH, Kocholaty WF, Shields CE. Hemoglobin function in stored blood. J Clin Invest 1969; 48: 311-321.

  2. García Escamilla RM, Méndez López TIA. Reacciones adversas por transfusión sanguínea en pacientes cardiópatas. Rev Mex Patol Clin 2006; 53(3): 139-145.

  3. Serrano VX. Hemotransfusión como factor de riesgo en cirugía cardiaca. Arch Cardiol Mex 2006; 76(2): 86-91.

  4. Rodríguez MH. TRALI: daño pulmonar agudo por transfusión. Rev Med IMSS 2004; 42(6): 501-506.

  5. Barba EJR. Transfusión de sangre y sus componentes: riesgos, beneficios e indicaciones. Rev Mex Patol Clin 2004; 51(2): 97-118.

  6. Nishiyama T, Hanaoka K. Free hemoglobin concentration in patients receiving massive blood transfusion during emergency surgery for trauma. Can J Anesth 2000; 47: 881-885.

  7. Estep TN, Pedersen RA, Miller TJ, Stupar KR. Characterization of erythrocyte quality during the refrigerated storage of whole blood containing di-(2-ethylhexyl) phthalate. Blood 1984; 64: 1270-1276.

  8. Cint C, Johansen JS, Swko F, Price PA, Nielsen HJ. Accumulation of the neutrophil-derived protein YKL-40 during storage of various blood components. Inflamm Res 2001; 50: 107-111.

  9. Nielsen HJ. Detrimental effects of perioperative blood transfusion. Bri J Surg 1995; 82: 582-587.

  10. Nielsen HJ, Werther K, Mynster T, Brünner N. Soluble vascular endothelial growth factor in various blood transfusion components. Transfusion 1999; 39: 1078-1083.

  11. Szpisjak D, Edgell DS, Bissonnette B. Potassium as a surrogate marker of debris in cell-salvaged blood. Anesth Analg 2000; 91: 40-43.

  12. Korgum DK, Bilmen S, Yesilkaya A. Alterations in the erythrocyte antioxidant system of blood stored in blood bags. Res Commun Mol Pathol Pharmacol 2001; 109: 357-363.

  13. Deepa DKV, Manoj KV, Arun P, Santhosh A. Increase lipid peroxidation of erythrocytes in blood stored in polyvinyl chloride blood storage bags plasticized with di-(2-ethyl hexyl) phthalate and effect of antioxidants. Vox Sang 1998; 75(3): 198-204.

  14. Hill HR, Oliver KC, Lippert LE, Greenwalt TJ, Hess JR. The effects of polyvinyl chloride and polyolefin blood bags on red blood cells stored in a new additive solution. Vox Sang 2001; 81(3): 161-166.

  15. Kim-Shapiro DB, Schechter AN, Gladwin MT. Unraveling the reactions of nitric oxide, nitrite and hemoglobin in physiology and therapeutics. Arterioscler Thromb Vasc Biol 2006; 26: 697-705.

  16. Ignarro LJ. Nitric oxide as a unique signaling molecule in the vascular system: a historical overview. J Physiol Pharmacol 2002; 53(4): 503-514.

  17. Stankevicius E, Kévelaitis E, Vainorius E, Simonsen U. Role of nitric oxide and other endothelium-derived factors. Medicina 2003; 39(4): 333-341.

  18. Manukhina EB, Downey HF, Mallet RT. Role of nitric oxide in cardiovascular adaptation to intermittent hypoxia. Exp Biol Med 2006; 231: 343-365.

  19. May JM, Zhi-Chao Q, Xia L, Cobb CE. Nitric uptake and metabolism and oxidant stress in human erythrocytes. Am J Physiol Cell Physiol 2000; 279: C1946-C1954.

  20. Gladwin MT, Schechter AN. NO contest: Nitrite versus S-nitroso-hemoglobin. Circ Res 2004; 94: 851-855.

  21. Recchia FA, Voger TR, Hintze TH. NO metabolites accumulate in erythrocytes in proportion to carbon dioxide and bicarbonate concentration. Am J Physiol Heart Circ Physiol 2000; 279: H852-H856.

  22. Gladwin MT, Wang X, Reiter CD, Yang BK. S-nitrosohemoglobin is unstable in the reductive erythrocyte environment and lacks O2/NO-linked allosteric function. J Biol Chem 2002; 277: 27818-27828.

  23. Rodkey FL. A mechanism for the conversion off oxyhemoglobin to methemoglobin by nitrite. Clin Chem 1976; 22(12): 1986-1990.

  24. Noble DN, Swift HR, Williams DLH. Nitric oxide release from S-nitrosoglutathione (GSNO). Chem Commun 1999; 18: 2317-2318.

  25. Noble DR, Williams DLH. Nitrosation products from S-nitrosothiols via preliminary nitric oxide formation. J Chem Soc Perkin Trans 2002; 2: 1834-1838.

  26. Van Der Lee I, Zanen P, Bidesma DH, van der Bosch JMM. The effect of red cell transfusion on nitric oxide diffusing capacity. Respiration 2004; 72: 512-516.

  27. Gutiérrez-Salinas J, Zentella de Piña M, Piña E. Acute ethanol intake produces lipid peroxidation in rat red blood cells membranes. Biochem Mol Biol Int 1993; 29: 263-270.

  28. Cortas NK, Wakid NW. Determination of inorganic nitrate in serum and urine by kinetic cadmium-reduction method. Clin Chem 1990, 38: 1440-1443.

  29. Kohn MC, Melnick RL, Ye F, Portier CJ. Pharmacokinetic of sodium nitrite-induced methemoglobinemia in the rat. Drug Metabolism and Disposition, 2002; 30: 676-683.

  30. Nagaprasad VA, Megha SA. Sequential analysis of the influence of blood storage on aggregation, deformability and shape parameters of erythrocytes. Clin Hemorhe Microcirc 1998; 18(4): 273-284.

  31. Sezdi M, Bayik Y, Ulgen Y. Storage effects on the cole-cole parameters of erythrocyte suspensions. Physiol Meas 2006; 27: 623-635.

  32. Bratosin D, Leszczynski S, Sartiaux C, Fontaine O. Improved storage of erythrocytes by prior leukodepletion: flow cytometric evaluation of stored erythrocytes. Cytometry 2001; 46(6): 351-356.

  33. Waltemath C. The effect of pH and blood gas correction on DPG and plasma potassium content of stored blood. Canad Anaesth Soc J 1975; 22: 164-170.

  34. Racer J, Herynkova R, Holecek V, Faltysova J, Krejcová I. What is the source of free radicals causing hemolysis in stored blood? Physiol Res 2001; 50: 383-388.

  35. Meyerstein N, Mazor D, Dvilansky. Erythrocyte agglomeration and survival studies in citrate-phosphate-dextrose (CPD) units. J Ann Hematol 1979; 39(3): 211-216.

  36. Hardy JF, Bélisle S. Erythrocyte transfusion: friend or foe? Can J Anesth 2001; 48(6): 1-7.

  37. Borghi B, Van Oven H. Reducing the risk of allogeneic blood transfusion. JAMC 2002; 166(3): 332-334.

  38. Denicola A, Souza JM, Radi R. Diffusion of peroxynitrite across erythrocyte membranes. Proc Natl Acad Sci USA 1998; 95: 3566-3571.




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