Morayta MGUC, Molinar RF, Vázquez HMI, Baltazar TJA, Hernández EG, Cano OA

Language: Spanish
References: 27
Page: 12-18
PDF size: 117.77 Kb.

ABSTRACT

Objective. To evaluate the effects of fentanyl compared with midazolam for sedation of patients supported with mechanical ventilation (AMV).
Design. An open and prospective study.
Setting. A 14-bed ICU of a tertiary care hospital of Mexico City.
Patients. A total of 40 consecutive patients with AMV.
Interventions. Forty adult patients were assigned to receive during 24 hours either fentanyl (group A [an initial dose of 3 µg/kg, followed by an infusion of 1-3 µg/kg/h]) or midazolam (group B [an initial bolus of 0.5-0.3 mg/kg, followed by an infusion of 0.05 -0.13 mg/kg/h).
Measurements and main results. The sedation level (Ramsay Escale) mean arterial pressure, central venous pressure (CVP) and heart rate were registered at 15, 30, 60, 240, 480, 720 and 1,440 minutes. The level of sedation at 30' was 4 ± 0.78 (group A) vs. 3.3 ± 0.9 (group B), p = 0.012. A significant increase of heart rate at 480 and 1,440 minutes and CVP at 24 hours was observed in group A (p ‹ 0.05).
Conclusion. Fentanyl is useful for sedation of ICU patients supported with mechanical ventilation.

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