2007, Number 2
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Gac Med Mex 2007; 143 (2)
Factores predictores de falla en la extubación en recién nacidos de pretérmino
Tapia-Rombo CA, Galindo-Alvarado AM, Saucedo-Zavala VJ, Cuevas-Urióstegui ML
Language: Spanish
References: 28
Page: 101-108
PDF size: 73.72 Kb.
ABSTRACT
Objective: To determine the factors that lead to extubation failure among preterm newborns (PTN).
Material and methods: Failure was determined when patients had to be reintubated during the first 72 hours. Critically-ill preterm newborns needing mechanical assisted ventilation at least during 24 hours were studied prospectively. Two groups were included: Group A, who failed in extubation for the first time and Group B, a control group who did not fail. Significance was set a p ‹0.05.
Results: Gestational age and birth weight showed significant differences in Group B (control group). Significant factors in the multivariate analysis were gestational age ‹32 weeks, caloric intake ≤100 calories/kg/day and mean airway pressure (MAP) =4.5 cm H
2O.
Conclusions: According to our results, an extubation should be planned whenever a patient is a PTN, has a gestational age of ‹32 weeks, a caloric intake ›100 cal/kg /day, and its ventilator MAP is ‹4.5 cm H
2O.
REFERENCES
Chan V, Greenough A. Comparison of weaning by patient triggered ventilation or synchronous intermittent mandatory ventilation in preterm infants. Acta Paediatr 1994;83:335-337.
Finer NN, Moriartey RR, Boyd J, Philips HJ, Stewart AR, Ulan O. Post extubation atelectasis:a retrospective review and a prospective controlled study. J Pediatr 79;94:110-113.
Goldsmith JP, Sharp MJ. Ventilatory management casebooks. En Goldsmith JP, Karotkin EH ed. Assisted ventilation of the neonate. 2nd Edition. Philadelphia:W.B. Saunders Company, 1988; pp. 409-429.
Nugent J, Matthews BJ, Goldsmith JP. Pulmonary care. En Goldsmith JP, Karotkin EH ed. Asisted ventilation of the neonate. 2nd Edition. Philadelphia: W.B. Saunders Company, 1988; pp. 90-106.
Carlo WA, Martin RJ. Principios de la ventilación asistida neonatal. Clin Pediatr Norteam 1986;1:231-248.
Kim EH, Boutwell WC. Successful direct extubation of very low birth weight infants from low intermittent mandatory ventilation rate. Pediatrics 1987;80:409-414.
Kavvadia V, Greenough A, Dimitriou G. Prediction of extubation failure in preterm neonates. Eur J Pediatr 2000;159:227-231.
Chan V, Greenough A. Randomized trial of methods of extubation in acute and chronic respiratory distress. Arch Dis Child 1993;68:570-572.
Dimitriou G, Greenough A, Laubscher B. Lung volume measurements immediately after extubation and prediction of “extubation failure” in premature infants. Pediatr Pulmonol 1996;21:250-254.
Dimitriou G, Greenough A, Kavvadia V, Laubscher B, Alexiou C, Pavlou V, Mantagos S. Elective use of nasal continuous positive airways pressure following extubation of preterm infants. Eur J Pediatr 2000;159:434-439.
Tapia JL, Bancalari A, González A, Mercado ME. Does continuous positive airway pressure (CPAP) during weaning from intermittent mandatory ventilation in very low birth weight infants have risks or benefits? A controlled trial. Pediatr Pulmonol 1995;19:269-274.
Couser RJ, Ferrara B, Falde B, Johnson K, Schilling CG, Hoekstra RE. Effectiveness of dexamethasone in preventing extubation failure in preterm infants at increased risk for airway edema. J Pediatr 1992;121:591-596.
Pellicer A, Gayá F, Stiris TA, Quero J, Cabañas F. Cerebral haemodynamics in preterm infants after exposure to dexamethasone. Arch Dis Child Fetal Neonatal Ed 1998;79:F123-F128.
Al-Alaiyan S, Dyer D, Khan B. Chest physioterapy and post-extubation atelectasis in infants. Pediatr Pulmonol 1996;21:227-230.
Davis PG, Henderson-Smart DJ. Intravenous dexamethasone for extubation of newborn infants. Cochrane Database Syst Rev 2001;(4):CD000308. Review.
Khalaf MN, Brodsky N, Hurley J, Bhandari V. A prospective randomized, controlled trial comparing synchronized nasal intermittent positive pressure ventilation versus nasal continuous positive airway pressure as modes of extubation. Pediatrics 2001;108:13-17.
Dimitriou G, Greenough A. Computer assisted analysis of the chest radiograph lung area and prediction of failure of extubation from mechanical ventilation in preterm neonates. Br J Radiol 2000;73:156-159.
Dimitriou G, Greenough A, Endo A, Cherian S, Rafferty GF. Prediction of extubation failure in preterm infants. Arch Dis Child Fetal Neonatal Edition 2002;86:F32-F35.
Halliday HL. What interventions facilate weaning from the ventilator? A review of the evidence from systematic reviews. Paediatr Respir Rev 2004;Suppl A:S347-S352.
Capurro H, Konchezky S, Fonseca D, Caldeyro-Barcia R. A simplified method for diagnosis of gestational age in the newborn infant. J Pediatr 1978;93:120-122.
Papile LA, Burstein J, Burstein R, Koffler H. Incidence and evolution of subependymal and intraventricular hemorrhage:a study of infants with birth weights less than 1,500 gm. J Pediatr 1978;92:529-534.
Young MJ, Bresnitz EA, Strom BL. Sample size nomograms for interpreting negative clinical studies. Ann Intern Med 1983;99:248-251.
Yeh TF, Raval D, Luken J, Thalji A, Lilien L, Pildes RS. Clinical evaluation of premature infants with patent ductus arteriosus: a scoring system with echocardiogram, acid-base, and blood gas correlations. Crit Care Med 1981;9:655-657.
Henderson-Smart DJ, Davis PG. Prophylactic methylxanthines for extubation in preterm infants. Cochrane Database Syst Rev 2003;(1):CD000139.
Stockman III JA. Anemia de la premadurez. Conceptos actuales sobre cuándo administrar una transfusión. Clin Pediatr Norteam 1986;1:115-133.
Corcoran JD, Patterson CC, Thomas PS, Halliday HL. Reduction in the risk of bronchopulmonary dysplasia from 1980 – 1990: results of a multivariate logistic regression analysis. Eur J Pediatr 1993;152:677-68l.
Garland SJ, Buck KR, Allred NE, Leviton A. Hypocarbia before surfactant therapy appears to increase bronchopulmonary dysplasia risk in infants with respiratory distress syndrome. Arch Pediatr Adolesc Med 1995;149:6l7-622.
Van Marter LJ, Allred EN, Pagano M, Sanocka U, Parad R, Moore M, Susser M, Paneth N, Leviton A. Do clinical markers of barotrauma and oxygen toxicity explain interhospital variation in rates of chronic lung disease?. The Neonatology Committee for the Developmental Network. Pediatrics 2000;105:1194- 120l.