Marroquín SR, Martínez RCF, García BMM, Calvillo ER, Mora GJLA, Flores PM

Language: English/Spanish
References: 16
Page: 347-357
PDF size: 493.06 Kb.

ABSTRACT

In this paper, the anti-Ro/SSA, anti-La/SSB and anti-phospholipid antibodies’ titers in serum of nude mutant mice of et/et, et/+ (heterozygous) and +/+ strains, were comparatively studied, and antibodies’ titers were correlated with the severity of maxillary and lacrimal glands’ lesions. Results showed that gross ocular lesions were associated to the mutant strain et/et. In this strain the glandular weight had a negative correlation with the age (r = –0.370, P = 0.011), the presence of anti-Ro/SSA and anti-La/SSB autoantibodies showed 13.5% and 10.5% of positivity, respectively, and both antibodies were associated to the et/et strain, only 1/5 of the sera gave positive to both autoantibodies. The ANOVA test of antiphospholipid antibody’s titers between the strains showed increased titers of IgM and IgG antibodies in the et/et strain, compared to the +/+ and et/+ strains (P = 0.00 and P = 0.004, respectively). The weight of the lacrimal glands showed a negative correlation with the presence of anti Ro/SSA antibodies (r = –0.381, P = 0.009). When the correlation was between these autoantibody titers and the age, the result was positive (r = 0.403, P = 0.006). The results of this research show that the mutant strain et/et presents signs that resemble the Sjögren syndrome.

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