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Órgano Oficial de la Asociación Mexicana de Hepatología

2008, Number 1

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Ann Hepatol 2008; 7 (1)

Sorafenib, a systemic therapy for hepatocellular carcinoma

Méndez-Sánchez N; Vásquez-Fernández F; Zamora-Valdés D; Uribe M

Language: Spanish
References: 62
Page: 46-51
PDF size: 248.04 Kb.


Text Extraction

Hepatocellular carcinoma is a lethal disease that requires a multidisciplinary approach and management. Surgical therapy offers long-term survival; however, few patients are candidates. There has been no accepted systemic therapy for this disease until recently. This article briefly discusses the role of RAS/RAF/MEK/ERK signaling pathway in the pathogenesis of the disease and the promising role of sorafenib for advanced disease.


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